衰老及其相关疾病:研究进展

IF 0.2 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

生物化学与生物物理进展 Pub Date : 2014-01-01 DOI:10.3724/SP.J.1206.2014.00036

Jun-Ping Liu

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引用次数: 1

摘要

随着细胞开始丧失各种细胞类型的功能，衰老就发生了。如果它先于其他组织和器官过早地发生在特定的组织或器官中，它会导致疾病的病理发展。如何治疗衰老细胞及其相关分子是抗衰老研究的一个挑战。最近的研究表明，在哺乳动物胚胎发育过程中，衰老是在生理条件下发生的，而对某些生命形式来说，衰老从来没有发生过。衰老涉及多种疾病，难以测量，也没有普遍的标记。因此，有必要了解在人类疾病中经历衰老的细胞类型，从而了解潜在的分子机制。本文综述了近年来的研究进展，包括:(1)细胞衰老的概念、分类及相关机制;(2)生理性衰老:发育程序性衰老;(3)组织稳态与衰老;(4)细胞复制性衰老及相关疾病:端粒与癌症预后、特发性肺纤维化、高血压;(5)非复制性细胞衰老及相关疾病:帕金森病、糖尿病;(6)衰老与长寿的物种多样性。

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Aging and related diseases: Research progress

Aging occurs with cell beginning to lose function in a variety of cell types. If it takes place in a given tissue or organ prematurely ahead of other tissues and organs,it causes pathological development of diseases. How to treat aging cells and associated molecules is a challenge in anti-aging research. It has been demonstrated recently that aging occurs under physiological conditions during embryonic development of mammals,and that to some life forms aging never occurs. Involved in diverse diseases,aging is difficult to be measured and does not have universal markers. It is thus essential to comprehend the types of cells that undergo aging in human diseases and thereby the underlying molecular mechanisms. This article discusses recent research advances including:(1) The concept,classification and relevant mechanisms of cell aging;(2) Physiological aging: Developmentally programmed senescence;(3) Tissue homeostasis and aging;(4) Cell replicative senescence and related diseases: telomeres and cancer prognosis,idiopathic pulmonary fibrosis,hypertension;(5) Non-replicative cell aging and related diseases: Parkinson disease and diabetes;(6) Species diversity in aging and longevity.

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来源期刊

生物化学与生物物理进展生物-生化与分子生物学

CiteScore

0.50

自引率

33.30%

发文量

6805

审稿时长

4 months

期刊介绍： Progress in Biochemistry and Biophysics is a monthly, peer-reviewed journal sponsored by Institute of Biophysics, The Chinese Academy of Sciences together with Biophysical Society of China. It started publication in 1974. It mainly reports on the latest developments in biochemistry, biophysics, molecular biology and neuroscience both in China and abroad. It contains several columns such as "reviews and monographs", "rapid and short communications", "research papers", "techniques and methods" and "academic discussions".