吡哆醇在实验条件下的抗应激作用

Лядова Т.І., Кратенко Г.С., Вовк К.В., Власенко О.О., Шерстюк Л.Л., Резніченко О.Г., Бєляєва Л.В.
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引用次数: 0

摘要

一般来说,应激反应这个术语的含义包括在细胞、组织和系统水平上发生的一整套标准的、刻板的、遗传的固定过程。动物实验对研究精神病理问题具有重要意义。在这类研究中,特别关注的是处于正常和病理之间的动物的行为。毕竟,了解生病的动物是如何受到压力影响的,对于理解人类在类似情况下的行为是很重要的。本研究旨在探讨实验性情绪应激条件下吡哆醇的抗应激作用及其对中枢神经系统色氨酸代谢的影响。吡哆醇是许多色氨酸交换酶系统的辅酶,当在EC条件下给药时,与对照组相比,在所有研究的大脑结构(皮层、茎、小脑和下丘脑)中色氨酸水平的降低具有统计学意义。与此同时,所有结构中的血清素水平都可靠地增加到控制值,而皮层中的血清素水平甚至超过了控制值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ANTISTRESS ACTION OF PYRIDOXINE UNDER EXPERIMENTAL CONDITIONS
Stress reaction in general the meaning of this term includes the entire set of standard, stereotypical, genetic fixed processes that take place at the cellular, tissue and system levels. Research on animals is of great importance in studying the problems of mental pathological conditions. Special attention in such studies, attention is paid to the behavior of animals that are on the border between normality and pathology. After all, understanding that how sick animals behave, on which are affected by stress, weighs a lot to understand how people behave in similar situations. The aim of the work is to investigate the anti-stress effect of pyridoxine and its effect on tryptophan metabolism in the central nervous system under conditions of experimental emotional stress. Pyridoxine, which is a coenzyme of many enzyme systems of tryptophan exchange, when administered under EC conditions, leads to a statistically significant, compared to the control, decrease in the level of tryptophan in all the studied structures of the brain: cortex, stem, cerebellum, and hypothalamus. At the same time, the level of serotonin in all structures reliably increases to control values, and in the cortex it even exceeds them.
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来源期刊
Pharmacy World & Science
Pharmacy World & Science 医学-药学
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