Effect of ethylthiosulfаnylate and Chrome(VI) on the pro/antioxidant system in rats blood

physiological solution daily for 7 days. Rats of groups VI and VII were intragastrically administered with ethylthio sulfanylate oily solution at a rate of 100 mg/kg of body weight daily for 14 days, than animals were intraperitoneally injected K 2 Cr 2 O 7 in a dose of 2,5 mg Cr(VI)/kg body weight daily for 7 (group VI) and 14 days (group VII). After the decapitation of the animals during thiopental anaesthesia, a blood samples were taken. It has been found that the introduction of bichromate of potassium in the blood of rats in groups III and IV shows an increase in the content of oxidative stress. Preliminary intragastric administration of ethylthiosulfanylate partially reduced the level of growth of hydroperoxides of lipids and thiobarbituric acid TBA­active products caused by the action of Cr(VI) in groups VI and VII and did not affect the level of carbonyl groups of proteins products, in particular lipid hydroperoxides, thiobarbituric acid (TBA­active products and carbonyl groups of proteins. The work of the glutathione link of an tioxidant protection under the influence of Cr(VI) was partially activated in group III, but suppressed in group IV. Ethylthiosulfanylate separately (group V) and in combination with Cr(VI) (groups VІ and VІІ) caused activation of glutathione reductase and increased GSN concentration in erythrocytes of rats compared with group ІІ. Superoxide dismutase and catalase activity of rat erythrocytes were increased by the action of Cr(VI) in groups III and IV in comparison with group I. However, with the effect of ethylthiosulfanylate in Cr(VI) complex, superoxide dismutase activity was increased in VII and catalase activity in VI and VII groups decreased, compared to group II.