血管平滑肌损伤的应变和应变速率依赖性

K. Barbee, Amit Bhavnani
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引用次数: 0

摘要

每年有超过35万例经皮冠状动脉血管成形术(球囊血管成形术)。对于由于动脉粥样硬化过程导致冠状动脉血管闭塞的患者,该手术为冠状动脉旁路手术提供了一种侵入性较小的选择。由于再狭窄的高发生率,其潜力尚未完全实现-由于血管平滑肌(VSM)的病理生长,以应对气球膨胀的创伤,血管迅速重新闭塞。尽管人们认识到平滑肌损伤是再狭窄过程中的起始事件,但尚未有系统的研究确定产生VSM损伤并引起再狭窄反应所需的机械负荷条件。在本研究中,我们建立了一个细胞培养模型来定义产生VSM损伤所需的加载条件。该模型系统可以精确控制施加的应变和应变速率,并根据膜损伤量化损伤的严重程度。细胞损伤阈值标准的确定将允许血管成形术过程进行修改,并可能实现自动化,以最小化VSM损伤并避免再狭窄反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Strain and Strain Rate Dependence of Vascular Smooth Muscle Injury
Over 350,000 percutaneous translumenal coronary angioplasty (balloon angioplasty) procedures are performed each year. This procedure offers a less invasive alternative to coronary by-pass surgery for patients whose coronary vessels have become occluded due to the process of atherosclerosis. Its potential has not been fully realized due to the high rate of restenosis — the rapid reocclusion of the vessel due to the pathological growth of the vascular smooth muscle (VSM) in response to the trauma of the balloon inflation. Despite the recognition of smooth muscle injury as an initiating event in the process of restenosis, there has been no systematic study to determine the mechanical loading conditions required to produce VSM injury and elicit the restenosis response. In this study, a cell culture model was developed to define the loading conditions required to produce VSM injury. The model system allows precise control of the applied strain and strain rate and quantification of the injury severity in terms of membrane damage. The determination of the threshold criteria for cell injury will allow the angioplasty procedure to be modified, and possibly automated, to minimize VSM injury and avoid the restenosis response.
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