Pharmaceutical forms and Drug-disease Interaction: An Old-new Case of Applying Pharmaceutical Knowledge

Theophylline is a drug that has been used for asthma disease, for more than 80 years. It has been used for its bronchodilator effects; however, dosing was critical because of it is narrow therapeutic index which may lead to failure in treatment of toxicity. This case illustrates the important of individualization of the theophylline based on the patient medical history. Pharmacist intervention and knowledge in the drug disease interaction, considering the pharmacokinetics data, would be valuable for the success of the treatment.