P5-02-11:早期ER+/Her2-乳腺癌有丝分裂活性指数、磷酸组蛋白H3、Ki67对肿瘤增殖的影响

J. Steenhoven, A. Kuijer, A. Leeuwen, J. Gorp, P. Diest, T. Dalen
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引用次数: 0

摘要

导读:通过有丝分裂指数或Ki67表达来判断肿瘤增殖的表达是乳腺癌最重要的预后因素之一,但其重复性并不理想。最近,磷酸组蛋白H3 (PHH3)被认为是一种新的有丝分裂特异性标志物。在本研究中,我们假设在HE 2019(12月10日至14日)中,PHH3阳性细胞的计数比有丝分裂计数更具可重复性;费城(PA): AACR;中国癌症杂志,2020;21(增刊):P5-02-11。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Abstract P5-02-11: Assessment of tumor proliferation by mitotic activity index, phosphohistone H3 and Ki67 in early stage ER+/Her2- breast cancer
Introduction: Determining expression of tumor proliferation by mitotic index or Ki67 expression is one of the strongest prognostic factors in breast cancer, but its reproducibility is not optimal. Recently, phosphohistone H3 (PHH3) was proposed as a novel marker specific for mitosis. For the present study, we hypothesized that counting PHH3 positive cells would be more reproducible than mitoses counting in HE 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P5-02-11.
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