职业接触4,4 -亚甲基双(2-氯苯胺)的高毒性和致癌性

Hong-I Chen
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引用次数: 0

摘要

4,4 -亚甲基双(2-氯苯胺)(MBOCA)是一种芳香二胺,广泛用作聚氨酯和环氧树脂的固化剂。下尿路癌最显著的风险因素是职业性暴露于芳香胺,1895年首次在英国发现。我们于2005年在台湾一家MBOCA制造工厂诊断出一例膀胱移行细胞癌的前哨病例。也没有关于工人暴露于MBOCA的日剂量或暴露途径的信息。然而,MBOCA是否会导致恶性肿瘤仍不清楚。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High toxicity and carcinogenesis of occupational exposure to 4, 4-methylenebis (2-chloroaniline) (MBOCA)
4,4 -Methylenebis (2-chloroaniline) (MBOCA) is an aromatic diamine used widely as a curing agent for polyurethane and epoxy resins. The most notable risk factor for the development of lower urinary tract cancers is occupational exposure to aromatic amines, first noted in England in 1895 [1]. A sentinel case of transitional cell carcinoma of the urinary bladder was diagnosed in an MBOCA manufacturing factory in Taiwan in 2005 [2]. There is also no information regarding the daily dose of MBOCA to which workers were exposed or the route of exposure [3]. However, it remains unclear whether MBOCA causes malignancy.
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