早期诊断口腔和潜在的口腔恶性病变:VELscope®荧光法的系统回顾

IF 0.5 Q4 DENTISTRY, ORAL SURGERY & MEDICINE
M. Cicciu', G. Cervino, L. Fiorillo, C. D’Amico, G. Oteri, G. Troiano, K. Zhurakivska, L. Lo Muzio, A. Herford, S. Crimi, A. Bianchi, D. Di Stasio, R. Rullo, G. Laino, L. Laino
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引用次数: 49

摘要

荧光法是病理学家用于身体粘膜检查和异常组织筛查的一种创新技术,可能导致早期发现癌前、癌或其他疾病过程。早期发现是使治疗成功、提高生存率和维持高生活质量的最佳机制之一。本综述的目的是评估该口腔诊断工具(VELscope®)的临床疗效。进行了文献系统综述。在应用纳入和排除标准后,最初的研究提供了53个结果,在作者对摘要进行人工筛选后,只有25个结果符合审查条件。所有不超过10年的研究结果和数据都进行了人工评估,并为该诊断方法提供了有用的信息。结果分析表明,VELscope®的敏感性平均值为70.19%,特异性平均值为65.95%,但尽管如此,一些研究对其临床疗效存在分歧,该诊断方法在科学和临床医学文献中仍存在争议。当然,从这个角度来看,能够拥有高效和有效的工具可以帮助临床医生进行诊断,也可以使药物或手术治疗更及时,提高患者的生活质量,在某些情况下保证更长的生存期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Early Diagnosis on Oral and Potentially Oral Malignant Lesions: A Systematic Review on the VELscope® Fluorescence Method
The fluorescence method is an innovative technique used by pathologists for examining body mucosa, and for the abnormalities tissue screening, potentially leading to the earlier discovery of pre-cancer, cancer or other disease processes. The early detection is one of the best mechanisms for enabling treatment success, increasing survival rates and maintaining a high quality of life. The purpose of this review is to evaluate the clinical efficiency of this diagnostic tool applied to the oral cavity (VELscope®). A literature systematic review has been performed. The initial research provided 53 results after applying the inclusion and exclusion criteria, and after a manual screening of the abstracts by the authors, only 25 results were eligible for review. The results and data contained in all the researches, no older than 10 years, were manually evaluated, and provided useful information on this diagnostic method. The VELscope® mean value about sensitivity and specificity resulted of 70.19% and 65.95%, respectively, by results analysis, but despite this some studies disagree about its clinical effectiveness, and this diagnostic method is still much debated in scientific and clinical medical literature. Surely being able to have efficient and effective tools from this point of view could help the clinician in the diagnosis, and also make timelier the pharmacological or surgical therapy, improving the quality of life of the patient, and in some cases guaranteeing a longer survival term.
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来源期刊
Open Dentistry Journal
Open Dentistry Journal DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
2.00
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0.00%
发文量
86
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