Mikio Nishikawa, Kazuichi Suzuki, S. Kachi, I. Kawakage, K. Fujii, H. Matsuda, K. Kanai
{"title":"注射油酸乙醇胺后血液中苯甲醇的浓度。","authors":"Mikio Nishikawa, Kazuichi Suzuki, S. Kachi, I. Kawakage, K. Fujii, H. Matsuda, K. Kanai","doi":"10.5649/jjphcs1975.13.226","DOIUrl":null,"url":null,"abstract":"The concentration of benzyl alcohol (BA) in the blood of the patients after the intravariceal injection of ethanolamine oleate (EO) with meglumine amidotrizoate (EO-MA) for endoscopic sclerotherapy of esophageal varices was determined by GLC method. BA appeared in the peripheral blood immediately after the interavariceal injection of EO-MA, therefore it was found that the leak of BA from the varix occurred very early. But BA disappeared rapidly from the blood (t1/2= 10 minutes). The hemolysis after the intravariceal injection had no relation to the concentration of BA in the blood.The actions of BA and EO on erythrocytes were examined in vitro, and the hemolyzing effect of EO was much stronger than that of BA. From these results, it is thought that the effect of BA on the hemolysis after the intravariceal injection of EO-MA is only a little and the hemolysis probably results from EO.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"51 1","pages":"226-230"},"PeriodicalIF":0.0000,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The concentration of benzyl alcohol in the blood after the injection of ethanolamine oleate.\",\"authors\":\"Mikio Nishikawa, Kazuichi Suzuki, S. Kachi, I. Kawakage, K. Fujii, H. Matsuda, K. Kanai\",\"doi\":\"10.5649/jjphcs1975.13.226\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The concentration of benzyl alcohol (BA) in the blood of the patients after the intravariceal injection of ethanolamine oleate (EO) with meglumine amidotrizoate (EO-MA) for endoscopic sclerotherapy of esophageal varices was determined by GLC method. BA appeared in the peripheral blood immediately after the interavariceal injection of EO-MA, therefore it was found that the leak of BA from the varix occurred very early. But BA disappeared rapidly from the blood (t1/2= 10 minutes). The hemolysis after the intravariceal injection had no relation to the concentration of BA in the blood.The actions of BA and EO on erythrocytes were examined in vitro, and the hemolyzing effect of EO was much stronger than that of BA. From these results, it is thought that the effect of BA on the hemolysis after the intravariceal injection of EO-MA is only a little and the hemolysis probably results from EO.\",\"PeriodicalId\":17399,\"journal\":{\"name\":\"Journal of the Nippon Hospital Pharmacists Association\",\"volume\":\"51 1\",\"pages\":\"226-230\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1987-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Nippon Hospital Pharmacists Association\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5649/jjphcs1975.13.226\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Nippon Hospital Pharmacists Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5649/jjphcs1975.13.226","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The concentration of benzyl alcohol in the blood after the injection of ethanolamine oleate.
The concentration of benzyl alcohol (BA) in the blood of the patients after the intravariceal injection of ethanolamine oleate (EO) with meglumine amidotrizoate (EO-MA) for endoscopic sclerotherapy of esophageal varices was determined by GLC method. BA appeared in the peripheral blood immediately after the interavariceal injection of EO-MA, therefore it was found that the leak of BA from the varix occurred very early. But BA disappeared rapidly from the blood (t1/2= 10 minutes). The hemolysis after the intravariceal injection had no relation to the concentration of BA in the blood.The actions of BA and EO on erythrocytes were examined in vitro, and the hemolyzing effect of EO was much stronger than that of BA. From these results, it is thought that the effect of BA on the hemolysis after the intravariceal injection of EO-MA is only a little and the hemolysis probably results from EO.
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