{"title":"4-{[(E) - 1h -吲哚-3h-甲基]氨基}- 1,5-二甲基-2-苯基-1,2-二氢-3h-吡唑-3 -1及其Al(Iii), In(Iii)和Tl(I)配合物的合成、表征和微生物初步研究","authors":"A. Ocheni, P. Ukoha, P. Onoja","doi":"10.3968/8519","DOIUrl":null,"url":null,"abstract":"4-{[(E)–1H–indol–3H–ylmethylidene]amino}–1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol–3-one and its Al(III), In(III) and Tl(I) Complexes have been synthesized and characterized by physical methods and spectral studies. All the complexes were purified and their structures were elucidated using melting point, stoichiometry, molar conductivity, UV-visible, infrared, nuclear magnetic resonance and GCMS Spectral Studies The geometry around the metals were deduced based on the spectral information and were found to be five coordinate in all the complexes. The Schiff base ligand is coordinated to the metals through the participation of its imine nitrogen, indole-nitrogen and the oxygen of the antipyrine moiety. These complexes were also tested against different bacteria and fungi using Agar well diffusion method to determine their antimicrobial potency and they were found sensitive against Escherichia Coli, Pseudomonas aeruginosa, Basillus subtilis and Candida albicans but none was found active against Staphylococcus aureus.","PeriodicalId":7348,"journal":{"name":"Advances in Natural Science","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Synthesis, Characterization and Preliminary Microbial Studies of 4-{[(E)–1h–Indol–3h–Lmethylidene]Amino}–1,5-Dimethyl-2-Phenyl-1,2-Dihydro-3h-Pyrazol–3-One and Its Al(Iii), In(Iii) and Tl(I) Complexes\",\"authors\":\"A. Ocheni, P. Ukoha, P. Onoja\",\"doi\":\"10.3968/8519\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"4-{[(E)–1H–indol–3H–ylmethylidene]amino}–1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol–3-one and its Al(III), In(III) and Tl(I) Complexes have been synthesized and characterized by physical methods and spectral studies. All the complexes were purified and their structures were elucidated using melting point, stoichiometry, molar conductivity, UV-visible, infrared, nuclear magnetic resonance and GCMS Spectral Studies The geometry around the metals were deduced based on the spectral information and were found to be five coordinate in all the complexes. The Schiff base ligand is coordinated to the metals through the participation of its imine nitrogen, indole-nitrogen and the oxygen of the antipyrine moiety. These complexes were also tested against different bacteria and fungi using Agar well diffusion method to determine their antimicrobial potency and they were found sensitive against Escherichia Coli, Pseudomonas aeruginosa, Basillus subtilis and Candida albicans but none was found active against Staphylococcus aureus.\",\"PeriodicalId\":7348,\"journal\":{\"name\":\"Advances in Natural Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-05-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Natural Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3968/8519\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Natural Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3968/8519","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis, Characterization and Preliminary Microbial Studies of 4-{[(E)–1h–Indol–3h–Lmethylidene]Amino}–1,5-Dimethyl-2-Phenyl-1,2-Dihydro-3h-Pyrazol–3-One and Its Al(Iii), In(Iii) and Tl(I) Complexes
4-{[(E)–1H–indol–3H–ylmethylidene]amino}–1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol–3-one and its Al(III), In(III) and Tl(I) Complexes have been synthesized and characterized by physical methods and spectral studies. All the complexes were purified and their structures were elucidated using melting point, stoichiometry, molar conductivity, UV-visible, infrared, nuclear magnetic resonance and GCMS Spectral Studies The geometry around the metals were deduced based on the spectral information and were found to be five coordinate in all the complexes. The Schiff base ligand is coordinated to the metals through the participation of its imine nitrogen, indole-nitrogen and the oxygen of the antipyrine moiety. These complexes were also tested against different bacteria and fungi using Agar well diffusion method to determine their antimicrobial potency and they were found sensitive against Escherichia Coli, Pseudomonas aeruginosa, Basillus subtilis and Candida albicans but none was found active against Staphylococcus aureus.