4-{[(E) - 1h -吲哚-3h-甲基]氨基}- 1,5-二甲基-2-苯基-1,2-二氢-3h-吡唑-3 -1及其Al(Iii), In(Iii)和Tl(I)配合物的合成、表征和微生物初步研究

A. Ocheni, P. Ukoha, P. Onoja
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引用次数: 1

摘要

合成了4-{[(E) - 1h -吲哚- 3h -基甲基]氨基}- 1,5-二甲基-2-苯基-1,2-二氢- 3h -吡唑-3 -酮及其Al(III), In(III)和Tl(I)配合物,并通过物理方法和光谱研究对其进行了表征。通过熔点、化学计量、摩尔电导率、紫外可见、红外、核磁共振和GCMS光谱等方法对配合物进行了纯化,并对其结构进行了分析。根据光谱信息推导出配合物金属周围的几何形状,发现所有配合物均为五坐标。希夫碱配体通过其亚胺氮、吲哚氮和安替吡啶部分的氧的参与与金属配合。用琼脂孔扩散法测定了这些复合物对不同细菌和真菌的抑菌活性,发现它们对大肠杆菌、铜绿假单胞菌、枯草Basillus和白色念珠菌敏感,但对金黄色葡萄球菌没有活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis, Characterization and Preliminary Microbial Studies of 4-{[(E)–1h–Indol–3h–Lmethylidene]Amino}–1,5-Dimethyl-2-Phenyl-1,2-Dihydro-3h-Pyrazol–3-One and Its Al(Iii), In(Iii) and Tl(I) Complexes
4-{[(E)–1H–indol–3H–ylmethylidene]amino}–1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol–3-one and its Al(III), In(III) and Tl(I) Complexes have been synthesized and characterized by physical methods and spectral studies. All the complexes were purified and their structures were elucidated using melting point, stoichiometry, molar conductivity, UV-visible, infrared, nuclear magnetic resonance and GCMS Spectral Studies The geometry around the metals were deduced based on the spectral information and were found to be five coordinate in all the complexes. The Schiff base ligand is coordinated to the metals through the participation of its imine nitrogen, indole-nitrogen and the oxygen of the antipyrine moiety. These complexes were also tested against different bacteria and fungi using Agar well diffusion method to determine their antimicrobial potency and they were found sensitive against Escherichia Coli, Pseudomonas aeruginosa, Basillus subtilis and Candida albicans but none was found active against Staphylococcus aureus.
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