Takeo Takeda, Masahiro Ogawa, J. Kitamoto, Takahiro Kyoya, M. Terada
{"title":"高葡萄糖增强皮肤增敏剂诱导的NRF2激活","authors":"Takeo Takeda, Masahiro Ogawa, J. Kitamoto, Takahiro Kyoya, M. Terada","doi":"10.2174/1874340402107010008","DOIUrl":null,"url":null,"abstract":"Hyperglycemia, blood glucose levels above 2.0 g/L, is one of the major pathophysiological factors causing late complications in diabetes [1, 2]. Reactive Oxygen Species (ROS) are increased by hyperglycemia [3]. Oxidative damage in individual cells may reach a sufficient threshold to cause DNA strand breaks and induce cell death [4]. Therefore, hyperglycemia-induced oxidative stress is one of the responsible factors for the pathology of diabetic complications.","PeriodicalId":22859,"journal":{"name":"The Open Toxicology Journal","volume":"5 1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"High Glucose Enhances Skin Sensitizer-induced NRF2 Activation In Vitro\",\"authors\":\"Takeo Takeda, Masahiro Ogawa, J. Kitamoto, Takahiro Kyoya, M. Terada\",\"doi\":\"10.2174/1874340402107010008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Hyperglycemia, blood glucose levels above 2.0 g/L, is one of the major pathophysiological factors causing late complications in diabetes [1, 2]. Reactive Oxygen Species (ROS) are increased by hyperglycemia [3]. Oxidative damage in individual cells may reach a sufficient threshold to cause DNA strand breaks and induce cell death [4]. Therefore, hyperglycemia-induced oxidative stress is one of the responsible factors for the pathology of diabetic complications.\",\"PeriodicalId\":22859,\"journal\":{\"name\":\"The Open Toxicology Journal\",\"volume\":\"5 1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-04-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Open Toxicology Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874340402107010008\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Toxicology Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874340402107010008","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
High Glucose Enhances Skin Sensitizer-induced NRF2 Activation In Vitro
Hyperglycemia, blood glucose levels above 2.0 g/L, is one of the major pathophysiological factors causing late complications in diabetes [1, 2]. Reactive Oxygen Species (ROS) are increased by hyperglycemia [3]. Oxidative damage in individual cells may reach a sufficient threshold to cause DNA strand breaks and induce cell death [4]. Therefore, hyperglycemia-induced oxidative stress is one of the responsible factors for the pathology of diabetic complications.
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