Role and Pathological Significance of Apoptosis Induced by Influenza Virus Infection

The role and pathological significance of apoptosis in an influenza virus-infected host has been hotly debated. Influenza virus-induced apoptosis was primarily thought to be a host defense mechanism to limit virus replication and eliminate viruses from the host; however, the virus has mechanisms not only to overcome but to utilize apoptosis for its efficient replication. Virus-induced apoptosis also plays a role in developing symptoms. Understanding the mechanisms underlying virus-induced apoptosis could enable us to conquer the threat of influenza.