白杨叶提取物对曲霉的急性毒性及抗真菌活性研究。黑色和白色念珠菌

Q4 Medicine

International Journal of Medical Toxicology and Legal Medicine Pub Date : 2020-01-01 DOI:10.5958/0974-4614.2020.00022.4

S. Fattepur, Mohd Maaruf Abdul Malik, Kiran Nilual, Ibrahim Abdullah, Eddy Yusuf, M. Asmani, María Fátima, M. Kaleemullah

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引用次数: 3

摘要

Pereskia bleo是一种常见的民间植物，被马来西亚当地社区用于其药用特性。采用标准的方法对白莲叶提取物进行了初步的植物化学定性研究。本研究旨在筛选枸杞提取物对曲霉的急性毒性和抗真菌活性。黑色和白色念珠菌。浸渍法制备PBL提取物。急性毒性试验采用经合组织的指导方针。最小抑制浓度(MIC)值测定连续稀释。采用Kirby-Baeur圆盘扩散法测定了提取物对真菌的抑菌活性。急性研究发现即使口服剂量达到2gm也是安全的。泡沫试验表明皂苷的存在。PBL提取物对黑曲霉和白色念珠菌的最低抑菌浓度(MIC)分别为25% v/v和100%v/v。枸杞提取物与伊曲康唑对白色念珠菌和黑曲霉具有协同作用。

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Acute toxicity and antifungal activity of Pereskia bleo leaves extracts against Aspergillu. niger and Candida albicans

Pereskia bleo is a common folk plant used by the local community in Malaysia for its medicinal properties. Pereskia bleo leaves extract (PBL extracts) was subjected to preliminary qualitative phytochemical investigation by using standard procedures. This study was aimed on screening the acute toxicity and antifungal activity of PBL extracts against Aspergillus. niger and Candida albicans. PBL extracts were prepared by maceration. Acute toxicity is carried out by using OECD guidelines. The Minimum Inhibitory Concentration (MIC) values were determined by serial dilution. The antifungal activities of the extracts against fungus were tested by using Kirby-Baeur Disk Diffusion Method. Acute study was found to be safe even upto 2gm oral route. The Froth Test indicates presence of Saponin. PBL extracts shows the highest Minimum Inhibitory Concentration (MIC) value in the 25% v/v against Aspergillus niger and 100%v/v against Candida albicans. PBL extracts demonstrated synergistic effect with itraconazole against Candida albicans and Aspergillus niger.

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来源期刊

International Journal of Medical Toxicology and Legal Medicine Medicine-Pathology and Forensic Medicine

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： To disseminate scientific information in relation to medico-legal work among all desirous medical , research and legal persons. To create literature in the medico-legal , toxicology , forensic sciences , forensic medicine, crime scene investigation and other related scientific fields. To promote scientific temperament in the nation building. To enhance research and writing of scientific articles and experiences. To develop creativity and positive outlook among concerned professionals.