腺苷受体信号在以癌症为重点的疾病中的作用

Mahmood Poorjam, Zeinabsadat Mohammadi, S. Jafari
{"title":"腺苷受体信号在以癌症为重点的疾病中的作用","authors":"Mahmood Poorjam, Zeinabsadat Mohammadi, S. Jafari","doi":"10.52547/jorjanibiomedj.10.1.41","DOIUrl":null,"url":null,"abstract":"Various investigation has shown the magnitude role of adenosine receptors in cancer development. The A1, A2A, A2B, and A3 G-protein-coupled cell surface Adenosine Receptors (ARs) are found to be upregulated in many types of cancers. The adenosine receptor function has been affected by specific ligands such as agonists and/or antagonists regulated cancer (Neoplasms) cells proliferation via signaling pathways. Adenosine not only is an important intermediate metabolite but also acts as the essential ligand of adenosine receptors in physiological and pathological conditions. Furthermore, many studies have shown that adenosine receptors expression has increased in many types of cancer. In this review, we first describe adenosine's role in physiological condition and in cancer development. We further, discuss the type of adenosine receptors, distribution, expression, and their roles in cancer.","PeriodicalId":14723,"journal":{"name":"Jorjani Biomedicine Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Adenosine Receptor Signaling in Diseases with Focus on Cancer\",\"authors\":\"Mahmood Poorjam, Zeinabsadat Mohammadi, S. Jafari\",\"doi\":\"10.52547/jorjanibiomedj.10.1.41\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Various investigation has shown the magnitude role of adenosine receptors in cancer development. The A1, A2A, A2B, and A3 G-protein-coupled cell surface Adenosine Receptors (ARs) are found to be upregulated in many types of cancers. The adenosine receptor function has been affected by specific ligands such as agonists and/or antagonists regulated cancer (Neoplasms) cells proliferation via signaling pathways. Adenosine not only is an important intermediate metabolite but also acts as the essential ligand of adenosine receptors in physiological and pathological conditions. Furthermore, many studies have shown that adenosine receptors expression has increased in many types of cancer. In this review, we first describe adenosine's role in physiological condition and in cancer development. We further, discuss the type of adenosine receptors, distribution, expression, and their roles in cancer.\",\"PeriodicalId\":14723,\"journal\":{\"name\":\"Jorjani Biomedicine Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Jorjani Biomedicine Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.52547/jorjanibiomedj.10.1.41\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jorjani Biomedicine Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.52547/jorjanibiomedj.10.1.41","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

摘要

各种研究表明腺苷受体在癌症发展中的重要作用。A1, A2A, A2B和A3 g蛋白偶联的细胞表面腺苷受体(ARs)在许多类型的癌症中被发现上调。腺苷受体的功能受到特定配体(如激动剂和/或拮抗剂)的影响,这些配体通过信号通路调节肿瘤细胞的增殖。腺苷不仅是一种重要的中间代谢物,而且在生理和病理条件下都是腺苷受体必不可少的配体。此外,许多研究表明腺苷受体的表达在许多类型的癌症中都有所增加。在这篇综述中,我们首先描述了腺苷在生理状态和癌症发展中的作用。我们进一步讨论了腺苷受体的类型、分布、表达及其在癌症中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Adenosine Receptor Signaling in Diseases with Focus on Cancer
Various investigation has shown the magnitude role of adenosine receptors in cancer development. The A1, A2A, A2B, and A3 G-protein-coupled cell surface Adenosine Receptors (ARs) are found to be upregulated in many types of cancers. The adenosine receptor function has been affected by specific ligands such as agonists and/or antagonists regulated cancer (Neoplasms) cells proliferation via signaling pathways. Adenosine not only is an important intermediate metabolite but also acts as the essential ligand of adenosine receptors in physiological and pathological conditions. Furthermore, many studies have shown that adenosine receptors expression has increased in many types of cancer. In this review, we first describe adenosine's role in physiological condition and in cancer development. We further, discuss the type of adenosine receptors, distribution, expression, and their roles in cancer.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信