前列腺癌分级:演变和观念的改变

Vijayalaxmi M Dhorigol, R. Kangle
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引用次数: 0

摘要

前列腺癌(PC)的分级系统是由Donald Gleason博士于1966年首次提出的。多年来,前列腺癌的组织学、临床诊断和治疗不断发展,导致Gleason系统首次由国际泌尿病理学会(ISUP)于2005年修订,最近在2014年修订。与原来的2 ~ 10分的格里森评分(GS)不同,现在的评分系统不再是2 ~ 5分,最低分为6分。2014年的新分级系统基于修订后的GS提出了5个分级组,产生的分级数量较少,预后差异最显著,可能有助于减少通过前列腺特异性抗原筛查检测到的低级别PC的过度治疗。本综述提供了Gleason分级系统的发展和修订的最新情况,并讨论了修订后的ISUP 2005、2014和2019的新分级系统的不足、优点和局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Grading of prostate cancer: Evolution and changing concepts
Grading system for prostatic cancer (PC) was first described in1966 by Dr. Donald Gleason. Over the years, histologic, clinical diagnosis and management of PCa have evolved, leading to revisions of the Gleason system first by the International Society of Urological Pathology (ISUP) in 2005 and more recently in 2014. Unlike the original Gleason score (GS) ranging from 2 to 10, the current system no longer assign Scores 2–5, the lowest score being 6. The new grading system of 2014 proposed Five Grade Groups based on revised GS which produces a smaller number of grades with the most significant prognostic differences and may contribute to a decrease in the overtreatment of low-grade PC detected by prostate-specific antigen screening. This review provides an update on the evolution and revision of the Gleason grading system, with a discussion on the deficiencies, benefits, and limitations of the revised and new grading system of ISUP 2005, 2014, and 2019.
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