甲状腺功能减退患者血清铜、锰、硒和锌的测定

I. A. Al-Juboori, Rafi Al-Rawi, Hussein Kadhem A-Hakeim
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引用次数: 25

摘要

甲状腺激素合成减少和循环甲状腺激素水平低导致生化和/或临床甲状腺功能减退。甲状腺激素缺乏导致许多代谢过程减慢。维持最佳的健康状态需要足够的碳水化合物、蛋白质和脂质,以及大量营养素、微量营养素和微量元素。本研究对血清中微量元素的含量进行了测定;测定甲状腺功能减退患者体内锌、铜、锰、硒的含量,并与正常人进行比较。73名甲状腺功能减退患者和50名正常健康对照者参加了本研究。血清锌、铜采用火焰原子吸收分光光度计测定,锰、硒采用无火焰原子吸收分光光度计测定。结果显示,甲状腺功能减退患者血清锌、硒水平显著低于对照组(p < 0.05)。本研究结果表明,这些微量元素在许多代谢过程中作为必需营养素或作为不同酶的辅助因子,直接或间接地促进了甲状腺功能减退。因此,本研究结果提示,锌、锰和硒的代谢在甲状腺功能减退症中是异常的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Estimation of Serum Copper, Manganese, Selenium, and Zinc in Hypothyroidism Patients
Decreased thyroid hormone synthesis and low levels of circulating thyroid hormones result in biochemical and/or clinical hypothyroidism. Deficiency of thyroid hormones causes many metabolic processes to slow down. The maintenance of optimal health requires an adequate supply of carbohydrates, proteins and lipids, and macronutrients, micronutrients, and trace elements. In this work, the serum content of the trace elements; Zn, Cu, Mn, and Se in hypothyroidism patients was determined and compared to that of normal subjects. Seventy three ypothyroid patients and fifty normal healthy control persons participated in this study. Serum zinc and copper were determined using flame atomic absorption spectrophotometer, while determination of manganese and selenium were done using flameless atomic absorption spectrophotometer. The results showed that serum zinc and selenium level of hypothyroidism patients are significantly lower (p 0.05) in serum copper. The results of this work as discussed indicate, the role of these trace elements in many metabolic process either as essential nutrients or as cofactors for different enzymes contributed directly or indirectly to the hypothyroidism. Consequently, the results of this study suggest that the metabolism of zinc, manganese, and selenium is abnormal in hypothyroidism disease.
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