{"title":"人干扰素与细胞生长抑制","authors":"H. Dahl","doi":"10.1111/J.1699-0463.1977.TB01674.X","DOIUrl":null,"url":null,"abstract":"Human leukocyte interferon (IF) inhibits the growth rate of homologous cells in culture. The growth inhibitory component, formerly separated from the antiviral component of human leukocyte IF by adsorption chromatography on albumin-agarose, is investigated. The properties of the component are compared with the accepted characteristics of IF. The growth inhibition is caused by a small molecule, unstable to pH 2 treatment with HCl, but stable to trichloro-acetic acid (TCA) and to proteolytic enzymes. The isolated growth inhibitor seems to be a dimer of molecular weight (mol wt.)˜2300. It is activated by heat treatment and lacks species specificity. The discrepancies in the properties of the growth inhibitor before before and after separation from IF are discussed.","PeriodicalId":75410,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section B, Microbiology","volume":"26 1","pages":"54-60"},"PeriodicalIF":0.0000,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"HUMAN INTERFERON AND CELL GROWTH INHIBITION\",\"authors\":\"H. Dahl\",\"doi\":\"10.1111/J.1699-0463.1977.TB01674.X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Human leukocyte interferon (IF) inhibits the growth rate of homologous cells in culture. The growth inhibitory component, formerly separated from the antiviral component of human leukocyte IF by adsorption chromatography on albumin-agarose, is investigated. The properties of the component are compared with the accepted characteristics of IF. The growth inhibition is caused by a small molecule, unstable to pH 2 treatment with HCl, but stable to trichloro-acetic acid (TCA) and to proteolytic enzymes. The isolated growth inhibitor seems to be a dimer of molecular weight (mol wt.)˜2300. It is activated by heat treatment and lacks species specificity. The discrepancies in the properties of the growth inhibitor before before and after separation from IF are discussed.\",\"PeriodicalId\":75410,\"journal\":{\"name\":\"Acta pathologica et microbiologica Scandinavica. Section B, Microbiology\",\"volume\":\"26 1\",\"pages\":\"54-60\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta pathologica et microbiologica Scandinavica. Section B, Microbiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1111/J.1699-0463.1977.TB01674.X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta pathologica et microbiologica Scandinavica. Section B, Microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/J.1699-0463.1977.TB01674.X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Human leukocyte interferon (IF) inhibits the growth rate of homologous cells in culture. The growth inhibitory component, formerly separated from the antiviral component of human leukocyte IF by adsorption chromatography on albumin-agarose, is investigated. The properties of the component are compared with the accepted characteristics of IF. The growth inhibition is caused by a small molecule, unstable to pH 2 treatment with HCl, but stable to trichloro-acetic acid (TCA) and to proteolytic enzymes. The isolated growth inhibitor seems to be a dimer of molecular weight (mol wt.)˜2300. It is activated by heat treatment and lacks species specificity. The discrepancies in the properties of the growth inhibitor before before and after separation from IF are discussed.
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