Electroneurography abnormality in Parkinson’s disease: a potential biomarker to help diagnosis

Parkinson’s disease (PD) is a common neurodegenerative disease, pathologically characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra. Although various biomarkers and imaging criteria for PD have been established, objective and reliable evaluation methods are still lacking. Electroneurography, as an objective measurement of evoked compound muscle action potentials, is used to assess the integrity of the peripheral nerve and is important in the diagnosis and differential diagnosis of PD with neuromuscular injury. Moreover, it provides references for the evaluation and quantification of the motor function in PD. Here, we summarize recent advances in clinical research of electroneurography in PD, including the peripheral nerve conduction velocity, needle electromyography, surface electromyography, and motion unit number estimation. The potential values of electroneurography in PD diagnosis are also involved.