山茶醇提物对柏氏疟原虫感染的糖尿病小鼠具有降糖作用，但缺乏抗疟作用。

Q4 Medicine

Nigerian Journal of Physiological Sciences Pub Date : 2021-12-31 DOI:10.54548/nigerjphysiolsci.v36i2.7

Mufliat Temitope Akinwunmi, R. Adisa, S. O. Aroyeun, O. Ademowo

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引用次数: 0

摘要

研究了山茶提取物(ECS)对四氧嘧啶诱导的糖尿病小鼠和伯氏疟原虫感染小鼠的体内抗疟和抗糖尿病活性。84只BALB/c小鼠被分为感染伯氏螺旋体的1组和2组，注射四氧嘧啶的2组和3组，分别给予蒸馏水、ECS (300mg/kg)、氯喹(CQ-10mg/kg)或二甲双胍(250mg/kg)。结果显示，经ECS处理的伯氏弓形虫感染小鼠和伯氏弓形虫糖尿病小鼠的寄生率均显著升高(p<0.05)。此外，ECS显著降低了糖尿病和柏氏糖尿病小鼠的血糖和PCV (p<0.05)。ECS在伯氏假体感染的糖尿病中再生胰岛细胞，但缺乏明显的抗疟疾活性。

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Ethanolic extract of Camellia sinensise licited hypoglycemic but lacked antimalarial properties in Plasmodium berghei-infected diabetic mice.

The in vivo antimalarial and antidiabetic activity of extract of Camellia sinensis (ECS) in alloxan-induced diabetic and Plasmodium berghei-infected mice were investigated. Eighty-four BALB/c mice divided into sets 1 & 2 infected with P. berghei and 2 & 3 injected with alloxan received either distilled water, ECS (300mg/kg), Chloroquine (CQ-10mg/kg) or Metformin (250mg/kg). Results showed significant increases (p<0.05) in percentage parasitaemia of P. berghei-infected mice treated with ECS and P. berghei-diabetic mice. Furthermore, ECS significantly decreased (p<0.05) blood glucose and PCV in diabetic and P. berghei-diabetic mice. ECS regenerated pancreatic islet cells in P. berghei-infected-diabetes but lacked appreciable antimalarial activity.

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来源期刊

Nigerian Journal of Physiological Sciences Medicine-Physiology (medical)

CiteScore

0.80

自引率

0.00%

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