lncRNA与小细胞肺癌

国际肿瘤学杂志 Pub Date : 2019-10-08 DOI:10.3760/CMA.J.ISSN.1673-422X.2019.10.011

Chao Ming, R. He, Yuan Sun, Linghan Tian, Guang-Li Zhao

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引用次数: 0

摘要

肺癌的发病率和死亡率均居首位，其中小细胞肺癌(SCLC)约占肺癌病例的15%。近年来，人们发现长链非编码RNA (lncRNA) (TUG1、CCAT2、PVT1、HOTTIP和HOTAIR)在SCLC的发展中发挥着重要作用。lncRNA可在转录、转录后和表观遗传水平调控相关基因的表达，影响SCLC的增殖、侵袭、转移和化疗耐药。关键词:小细胞肺癌;RNA，长链非编码

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lncRNA and small cell lung cancer

The incidence and mortality of lung cancer rank first, and small cell lung cancer (SCLC) accounts for about 15% of lung cancer cases. In recent years, it has been found that long non-coding RNA (lncRNA) (TUG1, CCAT2, PVT1, HOTTIP and HOTAIR) plays a significant role in the development of SCLC. lncRNA can regulate the expression of related genes at the transcriptional, posttranscriptional and epigenetic levels, and it can infulence proliferation, invasion, metastasis and chemotherapy resistance of SCLC. Key words: Small cell lung carcinoma; RNA, long noncoding

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国际肿瘤学杂志

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