{"title":"小鼠发育中TGF-β相关信号系统","authors":"Brigid L.M. Hogan","doi":"10.1016/S1044-5781(06)80051-4","DOIUrl":null,"url":null,"abstract":"<div><p>Secreted polypeptide signalling molecules of the TGF- superfamily play critical roles during mouse development. There are 20 known members of this diverse family in the mouse, including the TGF-s, inhibin/activins, BMPs, GDFs, and nodal. Mutations in genes for some of these ligands have been identified or created by targeted mutagenesis. A complex network of binding proteins, proteases, and receptors is involved in the processing, presentation and biological activity of TGF-β-related ligands. It is likely that variations in these modifying factors will explain how different genetic backgrounds can influence the severity and penetrance of mutant phenotypes.</p></div>","PeriodicalId":101155,"journal":{"name":"Seminars in Developmental Biology","volume":"6 4","pages":"Pages 257-265"},"PeriodicalIF":0.0000,"publicationDate":"1995-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1044-5781(06)80051-4","citationCount":"9","resultStr":"{\"title\":\"The TGF-β-related signalling system in mouse development\",\"authors\":\"Brigid L.M. Hogan\",\"doi\":\"10.1016/S1044-5781(06)80051-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Secreted polypeptide signalling molecules of the TGF- superfamily play critical roles during mouse development. There are 20 known members of this diverse family in the mouse, including the TGF-s, inhibin/activins, BMPs, GDFs, and nodal. Mutations in genes for some of these ligands have been identified or created by targeted mutagenesis. A complex network of binding proteins, proteases, and receptors is involved in the processing, presentation and biological activity of TGF-β-related ligands. It is likely that variations in these modifying factors will explain how different genetic backgrounds can influence the severity and penetrance of mutant phenotypes.</p></div>\",\"PeriodicalId\":101155,\"journal\":{\"name\":\"Seminars in Developmental Biology\",\"volume\":\"6 4\",\"pages\":\"Pages 257-265\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1044-5781(06)80051-4\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in Developmental Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1044578106800514\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Developmental Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1044578106800514","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The TGF-β-related signalling system in mouse development
Secreted polypeptide signalling molecules of the TGF- superfamily play critical roles during mouse development. There are 20 known members of this diverse family in the mouse, including the TGF-s, inhibin/activins, BMPs, GDFs, and nodal. Mutations in genes for some of these ligands have been identified or created by targeted mutagenesis. A complex network of binding proteins, proteases, and receptors is involved in the processing, presentation and biological activity of TGF-β-related ligands. It is likely that variations in these modifying factors will explain how different genetic backgrounds can influence the severity and penetrance of mutant phenotypes.
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