MTHFR基因可预测未用药的双相情感障碍患者的体重变化

Brain disorders & therapy Pub Date : 2015-10-05 DOI:10.4172/2168-975X.S1.006

Reeta Jaya Philip Sneha Mareen Varghese B S Premalatha, Anita Reddy

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摘要

目的:BP-II患者代谢紊乱和肥胖的患病率高于普通人群。亚甲基四氢叶酸还原酶(MTHFR)基因的遗传变异被认为是精神分裂症患者体重增加的预测因素。在本研究中，我们研究了MTHFR C677T多态性是否可以预测BP-II患者治疗12周后代谢指标的变化。

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The MTHFR gene predict weight change in drug-naive patients with bipolar II disorder

Objective: Patients with BP-II have a higher prevalence rate of metabolic disturbance and obesity than do the general population. Genetic variants of the methylene tetrahydrofolate reductase (MTHFR) gene have been regarded as predictors of weight gain in schizophrenia. In the present study, we investigated whether the MTHFR C677T polymorphism may predict changes in metabolic indices after 12 weeks of treatment in patients with BP-II.

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Brain disorders & therapy

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