雷公藤叶化学成分及其细胞毒活性研究

Journal of Chemical Research-s Pub Date : 2022-01-01 DOI:10.1177/17475198211062836

Zhi-Chao Jiang, Zi-Heng Li, Peng Li

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引用次数: 0

摘要

从雷公藤(Tripterygium wilfordii)叶etoac可溶提取物中分离得到新的黄酮醇苷衍生物山奈酚(kaempferol 3-O-trans-p-coumaroyl-7-O-α- -鼠李糖苷(rhamnoside)(1)和5个已知化合物(2-6)。通过光谱和理化分析对新化合物的结构进行了鉴定。所有分离物对HepG2、Hep3B、A549和MCF-7四种人癌细胞进行体外细胞毒活性评价。其中化合物1对HepG2和Hep3B细胞具有显著的细胞毒活性，IC50值分别为6.8±1.6 μM和4.2±1.3 μM。以上数据证明了1治疗肝癌的潜力。4对HepG2和Hep3B细胞也有中等抑制作用，IC50值分别为16.1±2.3 μM和10.7±1.8 μM。

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Chemical constituents from the leaves of Tripterygium wilfordii and their cytotoxic activity

A new flavonol glycoside derivate named kaempferol 3-O-trans-p-coumaroyl-7-O-α-ʟ-rhamnoside (1), together with five known compounds (2–6), was isolated from the EtOAc-soluble extract of the leaves of Tripterygium wilfordii. The structure of new compound was elucidated with spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro cytotoxic activity against four human cancer cells including HepG2, Hep3B, A549 and MCF-7. Among them, compound 1 exhibited the significant cytotoxic activities against HepG2 and Hep3B cells with IC50 values of 6.8 ± 1.6 and 4.2 ± 1.3 μM, respectively. The above data demonstrated the potential of 1 for the treatment of liver cancer. In addition, 4 also showed moderate inhibitory activity on HepG2 and Hep3B cells with IC50 values of 16.1 ± 2.3 and 10.7 ± 1.8 μM, respectively.

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来源期刊

Journal of Chemical Research-s 化学科学, 有机化学, 有机合成

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Chemical Research is a peer reviewed journal that publishes full-length review and research papers in all branches of experimental chemistry. The journal fills a niche by also publishing short papers, a format which favours particular types of work, e.g. the scope of new reagents or methodology, and the elucidation of the structure of novel compounds. Though welcome, short papers should not result in fragmentation of publication, they should describe a completed piece of work. The Journal is not intended as a vehicle for preliminary publications. The work must meet all the normal criteria for acceptance as regards scientific standards. Papers that contain extensive biological results or material relating to other areas of science may be diverted to more appropriate specialist journals. Areas of coverage include: Organic Chemistry; Inorganic Chemistry; Materials Chemistry; Crystallography; Computational Chemistry.