Razieh Bayramlou, M. Mohammadzadeh, F. B. Balderlou
{"title":"氟西汀与丙咪嗪对固定应激下雄性大鼠抑郁样行为及血清皮质酮和葡萄糖水平影响的比较研究","authors":"Razieh Bayramlou, M. Mohammadzadeh, F. B. Balderlou","doi":"10.29252/qums.12.2.1","DOIUrl":null,"url":null,"abstract":"Methods: In this experimental study, 24 male Wistar rats (age range, 180±20gr), were used. Animals were divided into four groups of 6 each, including: Control, under immobilization stress, fluoxetinetreated (dose, 20mg/kg), and the Imipramine-treated (dose, 30mg/kg). Induction of immobilization stress was conducted by limiting polyethylene for 14 days. At the end of the treatment period, the antidepressant effects of the drugs in the treatment groups, were evaluated using tail suspension test. Then, serum levels of corticosterone and glucose, were measured.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"A Comparative Survey of the Effects of Fluoxetine and Imipramine on Depression-Like Behavior and Serum Levels of Corticosterone and Glucose in Male Rats under Immobilization Stress\",\"authors\":\"Razieh Bayramlou, M. Mohammadzadeh, F. B. Balderlou\",\"doi\":\"10.29252/qums.12.2.1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Methods: In this experimental study, 24 male Wistar rats (age range, 180±20gr), were used. Animals were divided into four groups of 6 each, including: Control, under immobilization stress, fluoxetinetreated (dose, 20mg/kg), and the Imipramine-treated (dose, 30mg/kg). Induction of immobilization stress was conducted by limiting polyethylene for 14 days. At the end of the treatment period, the antidepressant effects of the drugs in the treatment groups, were evaluated using tail suspension test. Then, serum levels of corticosterone and glucose, were measured.\",\"PeriodicalId\":20865,\"journal\":{\"name\":\"Qom University of Medical Sciences Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-04-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Qom University of Medical Sciences Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.29252/qums.12.2.1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Qom University of Medical Sciences Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29252/qums.12.2.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A Comparative Survey of the Effects of Fluoxetine and Imipramine on Depression-Like Behavior and Serum Levels of Corticosterone and Glucose in Male Rats under Immobilization Stress
Methods: In this experimental study, 24 male Wistar rats (age range, 180±20gr), were used. Animals were divided into four groups of 6 each, including: Control, under immobilization stress, fluoxetinetreated (dose, 20mg/kg), and the Imipramine-treated (dose, 30mg/kg). Induction of immobilization stress was conducted by limiting polyethylene for 14 days. At the end of the treatment period, the antidepressant effects of the drugs in the treatment groups, were evaluated using tail suspension test. Then, serum levels of corticosterone and glucose, were measured.
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