{"title":"自身免疫性结缔组织疾病患者血清对EBNA多肽的免疫印迹反应性","authors":"J. Ngou, M. Segondy","doi":"10.1016/S0888-0786(96)80008-4","DOIUrl":null,"url":null,"abstract":"<div><p>The antibody responses to Epstein-Barr nuclear antigen (EBNA) polypeptides were analyzed by immunoblotting in 93 patients with autoimmune connective tissue diseases (ACTD) in comparison with 50 clinically healthy control subjects. Antibody frequencies to EBNA-2, -4 and -6 were signficantly higher in patients than in controls. Among the patients with ACTD, those with systemic lupus erythematosus (SLE) showed a significant increase in the frequency of anti-EBNA-3 antibodies. These results confirm the particularity of the antibody responses against Epstein-Barr virus (EBV) polypeptides in patients with ACTD; they could either reflect basic immune disturbances or suggest a participation of EBV in the pathogenesis of the disease.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"8 2","pages":"Pages 105-108"},"PeriodicalIF":0.0000,"publicationDate":"1996-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0888-0786(96)80008-4","citationCount":"2","resultStr":"{\"title\":\"Immunoblotting reactivity of sera from patients with autoimmune connective tissue diseases against Epstein-Barr nuclear antigen (EBNA) polypeptides\",\"authors\":\"J. Ngou, M. Segondy\",\"doi\":\"10.1016/S0888-0786(96)80008-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The antibody responses to Epstein-Barr nuclear antigen (EBNA) polypeptides were analyzed by immunoblotting in 93 patients with autoimmune connective tissue diseases (ACTD) in comparison with 50 clinically healthy control subjects. Antibody frequencies to EBNA-2, -4 and -6 were signficantly higher in patients than in controls. Among the patients with ACTD, those with systemic lupus erythematosus (SLE) showed a significant increase in the frequency of anti-EBNA-3 antibodies. These results confirm the particularity of the antibody responses against Epstein-Barr virus (EBV) polypeptides in patients with ACTD; they could either reflect basic immune disturbances or suggest a participation of EBV in the pathogenesis of the disease.</p></div>\",\"PeriodicalId\":101161,\"journal\":{\"name\":\"Serodiagnosis and Immunotherapy in Infectious Disease\",\"volume\":\"8 2\",\"pages\":\"Pages 105-108\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0888-0786(96)80008-4\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Serodiagnosis and Immunotherapy in Infectious Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0888078696800084\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Serodiagnosis and Immunotherapy in Infectious Disease","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0888078696800084","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Immunoblotting reactivity of sera from patients with autoimmune connective tissue diseases against Epstein-Barr nuclear antigen (EBNA) polypeptides
The antibody responses to Epstein-Barr nuclear antigen (EBNA) polypeptides were analyzed by immunoblotting in 93 patients with autoimmune connective tissue diseases (ACTD) in comparison with 50 clinically healthy control subjects. Antibody frequencies to EBNA-2, -4 and -6 were signficantly higher in patients than in controls. Among the patients with ACTD, those with systemic lupus erythematosus (SLE) showed a significant increase in the frequency of anti-EBNA-3 antibodies. These results confirm the particularity of the antibody responses against Epstein-Barr virus (EBV) polypeptides in patients with ACTD; they could either reflect basic immune disturbances or suggest a participation of EBV in the pathogenesis of the disease.
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