埃塞俄比亚一家医院接受HAART治疗的成年HIV/AIDS患者齐多夫定诱发贫血的发生率评估

Muluken Wubetu, Epherem Mebratu
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引用次数: 5

摘要

背景:齐多夫定是埃塞俄比亚一线抗逆转录病毒治疗方案中的一种核苷类逆转录酶抑制剂。然而,已知它与贫血等危及生命的毒性有关。不幸的是,Mizan-Aman总医院的齐多夫定相关性贫血在以前还没有发现。因此,本研究的目的是确定在接受高效抗逆转录病毒治疗的成人HIV/AIDS患者中齐多夫定诱发贫血的患病率。方法:采用回顾性横断面研究设计,对米赞安曼总医院ART药房进行患者病历观察。采用简单随机抽样方法选择图表。通过随机抽取开始AZT含ART方案的患者病历中的记录信息来收集数据。结果:大约三分之一的参与者(27.9%)年龄在32 - 38岁之间。在评估的患者图表中,女性患者的图表占51.9%。超过三分之二的参与者(73.7%)是城市居民,而研究中约40%的患者(39.1%)是中学优等生,但11.9%的参与者是文盲。约五分之一(22.6%)的患者出现贫血。齐多夫定致贫血在文盲中发生率较高(29.4%)。在使用社会药物的同时发生AZT引起的贫血的人数相对较低,为14.1%。大多数贫血患者的基线血红蛋白水平≤12 g/dl(75.3%)。结论:AZT致贫血发生率在基线Hgb≤12 g/dl的患者中最高。频繁监测以AZT为基础的方案患者的血红蛋白浓度将是克服贫血本身和贫血相关费用(如输血)的基本策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of the Prevalence of Zidovudine Induced Anemia among Adult HIV/AIDS Patients on HAART in an Ethiopian Hospital
Background: Zidovudine is one of a nucleoside reverse transcriptase inhibitor in the first line ART regimen in Ethiopia. It is, however, known to be associated with life threatening toxicity like anemia. Unfortunately, zidovudine related anemia at Mizan-Aman General Hospital has not yet been known before. Therefore, the aim of this study is to determine the prevalence of zidovudine induced anemia among adult HIV/AIDS patients on highly active antiretroviral therapy. Methods: Retrospective cross-sectional study design was conducted in ART pharmacy in Mizan-Aman General Hospital by observing patient charts. Simple random sampling technique was used to select the charts. Data was collected by randomly extracting documented information in the patients’ medical chart who initiated AZT containing ART regimen. Result: Around on third of the participants (27.9%) were in the age range of 32 – 38 years. Of the assessed patient charts, charts with female patients constitute 51.9%. More than two-third of participants (73.7%) were urban residents while about forty percent of the total patients included in the study (39.1%) were secondary school achievers but 11.9% of participants were illiterate. About one fifth of the patients (22.6%) developed anemia. The occurrence of zidovudine induced anemia was higher among illiterates (29.4%). The number of participants who developed AZT induced anemia while using social drugs was relatively lower 14.1%. Majority of patients who developed anemia had a baseline hemoglobin level of ≤ 12 g/dl (75.3%). Conclusion: The prevalence of AZT induced anemia was found to be highest on patients whose baseline Hgb level ≤ 12 g/dl. Frequent monitoring of Hgb concentration in patients on AZT based regimen will be an essential strategy to overcome anemia itself and anemia related costs like blood transfusion.
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