Predictors of Health-Related Quality of Life in Sarcopenic Patients: Result from BCAAS Study

Background: Liver cirrhosis is a major burden that includes marked metabolic dysfunction and sarcopenia which may influence patients’ HRQoL. The main aim of the study was to analyse the mental, physical, and social well-being in sarcopenic population with liver cirrhosis (LC) using Chronic Liver Disease Questionnaire (CLDQ). Methods: The six domains of CLDQ were applied in a cross-sectional study during the 18 months of research in Rajasthan, India. Severity of the liver disease was determined through CTP and MELD. For the physical evaluation of sarcopenia, participants had undergone TAMA, hand grip strength, and gait speed test. For the statistical analysis, mean, SD, median, interquartile range, and multi logistic regression was used for final analysis. The total sample size was 138 patients. Result: The mean age of participants was 47.42±13.47 years, alcohol induced cirrhosis was the major factor contributing LC. CLDQ showed association with CTP, Meld Na, Ascites and Sarcopenia. CTP and MELD Na had an inverse effect with all domains of CLDQ and it showed a direct association with TAMA, hand grip strength and gait speed test. Conclusion: LC sarcopenic patients do worst in the domains of CLDQ that impair the health-related quality of life, as evidenced by CTP and MELD scores.