在抗生素神经系统副作用的观察性研究中，使用天然地层检查未测量偏差

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-02-23 DOI:10.1093/jrsssc/qlad010

K. Brumberg, Darcy E. Ellis, D. Small, S. Hennessy, P. Rosenbaum

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引用次数: 0

摘要

氟喹诺酮类药物是一种广泛使用的抗生素，美国食品和药物管理局警告说，这种药物可能对中枢和周围神经系统产生副作用。我们比较了436,891例使用氟喹诺酮类药物治疗的鼻窦炎患者与使用阿奇霉素或阿莫西林治疗的对照组。除了寻找神经系统并发症外，我们还使用未预料到的结果寻找偏倚的证据。比较使用“自然地层”，形成与处理组成比例的对照组，并平衡定义地层之外的许多协变量。主要的技术贡献是提出了一种多群天然地层近最优施工的新方法。在线补充材料包含证据、细节和有关R包的natstrat和复制的信息。

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Using natural strata when examining unmeasured biases in an observational study of neurological side effects of antibiotics

Fluoroquinolones are widely prescribed antibiotics that carry a US Food and Drug Administration warning about possible side-effects on the central and peripheral nervous system. We compare 436,891 patients with sinusitis treated with fluoroquinolones to two control groups treated with azithromycin or amoxicillin. In addition to looking for nervous system complications, we look for evidence of bias using outcomes for which an effect was not anticipated. The comparison uses ‘natural strata’ that form control groups proportional in size to the treated group and balance many covariates beyond those that define the strata. The main technical contribution is a new method for near-optimal construction of natural strata with multiple groups. The online supplement material contains proofs, details, and information about the R package natstrat and replication.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.