高脂饲粮/链脲佐菌素诱导的糖尿病Wistar大鼠血血红蛋白和堆积细胞体积(PCV)

A. T. Nnadiukwu, C. Monago-Ighorodje, L. C. Chuku
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引用次数: 0

摘要

目的:研究阿菊白芷合剂乙醇提取物对糖尿病大鼠血液学指标的影响。样品:用阿菊黄合剂乙醇提取物处理糖尿病大鼠,测定其堆积细胞体积(PCV)和血红蛋白(Hb)浓度。研究设计:实验过程中,54只初始体重为30 ~ 40g的大鼠,每组9只,分为6只。第一组为正常对照组(NC),其余5组采用高脂饮食和35 mg/kg体重链脲佐菌素诱导2型糖尿病8周。II组作为糖尿病对照组,其余组(III, IV, V和VI)分别给予二甲双胍和三种不同浓度的植物提取物。研究地点和时间:研究于2018年7月至2019年1月在哈科特港大学基础临床科学学院药学系动物馆进行。方法:在治疗第4周、第8周和第12周后,使用MINDRAY自动血液学分析仪评估血红蛋白和堆积细胞体积。结果:与正常对照组及其他治疗组相比,糖尿病对照组的PCV和血红蛋白浓度显著(P< 0.05)降低。结论:阿朱白芷合剂具有合成血细胞的倾向,是一种造血剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Haemoglobin and Packed Cell Volume (PCV) of High-Fat Diet/Streptozotocine-Induced Diabetic Wistar Rats Treated with Ethanol Extract of a Herbal Mixture (Aju Mbaise)
Aim: This study was carried out to evaluate the effect of ethanol extract of Aju Mbaise herbal mixture on some haematological indices of diabetic Wistar albino rats. Sample: Packed cell volume (PCV) and haemoglobin (Hb) concentration was estimated in diabetic rats treated with ethanol extract of Aju Mbaise herbal mixture. Study Design: In the course of the experiment, fifty-four (54) rats with initial weight range of 30 – 40 g were grouped into 6 of 9 rats per group. The first group served as the normal control (NC) while the remaining five groups were induced with diabetes type 2 using high-fat diet for 8 weeks and streptozotocin at 35 mg/kg body weight. Group II served as the diabetic control while the remaining groups (III, IV, V & VI) were treated with metformin and three different concentrations of the plant extract respectively. Place and Duration of Study: The study was carried out in the Animal house of the Department of Pharmacology, Faculty of Basic Clinical Sciences, University of Port Harcourt, between July 2018 and January 2019. Methodology: The haemoglobin and packed cell volume were estimated after 4th, 8th and 12th week of treatment using MINDRAY Auto-Haematology analyzer. Results: From the results obtained, it was observed that the diabetic control group has a PCV and haemoglobin concentration that is significantly (P<.05) lower when compared to that of the normal control group and the other treated groups. Conclusion: The study has shown that Aju Mbaise herbal mixture is a haematopoietic agent as it had the tendency to synthesize blood cells.
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