透明质酸作为非手术治疗Peyronie病的现有证据:当代回顾

IF 0.4 Q4 MATHEMATICS, APPLIED
M. Capece, G. Celentano, R. La Rocca
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引用次数: 0

摘要

佩罗尼氏病是一种以白膜纤维斑块形成为特征的疾病,可引起疼痛、弯曲和勃起功能障碍。临床前研究已经证明透明质酸在治疗Peyronie病方面的潜在益处,包括抗纤维化、抗炎和促血管生成作用,尽管还需要更多的研究来充分了解其作用机制。临床研究已经显示出令人鼓舞的结果,注射透明质酸可以改善斑块大小、阴茎弯曲度和勃起功能,并且患者耐受性良好。研究结果表明,注射血凝素可能是一种可行且安全的治疗Peyronie病的选择,特别是在疾病的早期阶段。然而,注射HA的最佳剂量和治疗时间,以及在Peyronie病稳定期的疗效,还需要更多的研究来确定。总的来说,透明质酸是一种潜在有效的Peyronie病的治疗方法,具有抑制纤维化和促进血管生成的能力,而且不良反应的风险低,使其成为不能或不愿接受手术的患者的一个有吸引力的选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Current Evidence on the Use of Hyaluronic Acid as Nonsurgical Option for the Treatment of Peyronie’s Disease: A Contemporary Review
Peyronie’s disease is a condition characterized by the formation of fibrous plaques in the tunica albuginea, which can cause pain, curvature, and erectile dysfunction. Preclinical studies have demonstrated the potential benefits of hyaluronic acid in treating Peyronie’s disease, including antifibrotic, anti-inflammatory, and proangiogenic effects, although more research is needed to fully understand its mechanisms of action. Clinical studies have shown promising results, with hyaluronic acid injections leading to improvements in plaque size, penile curvature, and erectile function, and being well tolerated by patients. The findings suggest that HA injections could be a viable and safe treatment option for Peyronie’s disease, particularly in the early stages of the disease. However, more research is needed to determine the optimal dosage and treatment duration for HA injections, and to confirm its efficacy in the stable phase of Peyronie’s disease. Overall, hyaluronic acid is a potentially effective therapy for Peyronie’s disease, with the ability to inhibit fibrosis and promote angiogenesis, and low risk of adverse effects, making it an attractive option for patients who are unable or unwilling to undergo surgery.
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来源期刊
CiteScore
0.80
自引率
20.00%
发文量
67
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