抗血管生成抗肿瘤药物致动脉高血压的诊断与治疗现状

E. Shavarova, E. Khachaturyan, I. Pokatayev, Z. Kobalava
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引用次数: 0

摘要

在肿瘤学中使用血管生成抑制剂(抗vgef抗体和酪氨酸激酶抑制剂)显著增加了肿瘤对治疗的反应和心血管毒性的风险。动脉高血压是抗血管生成治疗的主要不良反应,经常限制血管生成抑制剂的剂量,尽管它也被认为是靶向治疗有效性的可能替代标志。2022年,欧洲心脏病学会关于预防和纠正抗肿瘤治疗心脏毒性的建议发表。本文就抗血管生成药物致动脉性高血压的诊断和治疗现状作一综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Current diagnosis and treatment of arterial hypertension induced by antiangiogenic antitumour agents
The use of angiogenesis inhibitors (anti-VGEF antibodies and tyrosine kinase inhibitors) in oncology significantly increases both the tumor response to therapy and the risk of cardiovascular toxicity. Arterial hypertension is the main adverse effect of antiangiogenic therapy frequently limiting the doses of angiogenesis inhibitors, although it is also considered as a possible surrogate marker of the effectiveness of targeted therapy. In 2022, the recommendations of the European Society of Cardiology on the prevention and correction of cardiotoxicity of antitumor therapy were published. The article reviews the current diagnosis and treatment of arterial hypertension induced by antiangiogenic medicines.
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