{"title":"烷基苯磺酸钠和镍对豚鼠皮肤的毒性","authors":"A. Mathur, R. Shanker","doi":"10.1081/CUS-100000337","DOIUrl":null,"url":null,"abstract":"Guinea pigs were dermally exposed to linear alkylbenzene sulphonate (LAS) or nickel or in combination. In general, lipid peroxidation, histamine contents, acid phosphatase, β-glucuronidase, alkaline phosphatase, and glutathione-S-transferase showed elevations when exposed simultaneously to LAS and Ni. The Ni contents also increased in the skin. Histologically the skin revealed more hyperkeratinization and degenerative changes when it was exposed simultaneously to LAS and Ni.","PeriodicalId":17547,"journal":{"name":"Journal of Toxicology-cutaneous and Ocular Toxicology","volume":"5 1","pages":"23 - 27"},"PeriodicalIF":0.0000,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"DERMAL TOXICITY OF LINEAR ALKYLBENZENE SULPHONATE AND NICKEL IN GUINEA PIGS\",\"authors\":\"A. Mathur, R. Shanker\",\"doi\":\"10.1081/CUS-100000337\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Guinea pigs were dermally exposed to linear alkylbenzene sulphonate (LAS) or nickel or in combination. In general, lipid peroxidation, histamine contents, acid phosphatase, β-glucuronidase, alkaline phosphatase, and glutathione-S-transferase showed elevations when exposed simultaneously to LAS and Ni. The Ni contents also increased in the skin. Histologically the skin revealed more hyperkeratinization and degenerative changes when it was exposed simultaneously to LAS and Ni.\",\"PeriodicalId\":17547,\"journal\":{\"name\":\"Journal of Toxicology-cutaneous and Ocular Toxicology\",\"volume\":\"5 1\",\"pages\":\"23 - 27\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Toxicology-cutaneous and Ocular Toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1081/CUS-100000337\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Toxicology-cutaneous and Ocular Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1081/CUS-100000337","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
DERMAL TOXICITY OF LINEAR ALKYLBENZENE SULPHONATE AND NICKEL IN GUINEA PIGS
Guinea pigs were dermally exposed to linear alkylbenzene sulphonate (LAS) or nickel or in combination. In general, lipid peroxidation, histamine contents, acid phosphatase, β-glucuronidase, alkaline phosphatase, and glutathione-S-transferase showed elevations when exposed simultaneously to LAS and Ni. The Ni contents also increased in the skin. Histologically the skin revealed more hyperkeratinization and degenerative changes when it was exposed simultaneously to LAS and Ni.
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