The Level of Tumor Necrosis Factor –alpha in Patients with Acute Coronary Syndrome

Objectives: This study was used to measure the level of tumor necrosis factor- alpha in patients with acute coronary syndrome. Method: A case control study was used; the level of tumor necrosis factor-alpha was measured in 39 patients with acute coronary syndrome (30male, 9female) & 20(12male, 8female) control group; risk factors (smoking, hypertension, diabetes mellitus), duration of staying in cardiac care unit & complications (recurrent angina pain, hemodynamic, electrical) are also recorded. Result: we were found significant increase in the level of tumor necrosis factor -alpha in all patients with acute coronary syndrome as compared with control group (P value< 0.01) the highest level of tumor necrosis factor -alpha are associated with myocardial infarction rather than unstable angina patients &also high rate of complications. Conclusion: According to this study tumor necrosis factor-alpha was significantly increased in acute coronary syndrome &could be used for determining severity of the diseases in patients with acute coronary syndrome.