含脯氨酸寡肽对近交ICR小鼠强迫游泳行为的影响

Q4 Medicine

Proceedings of the National Academy of Sciences of Belarus, Medical series Pub Date : 2023-09-01 DOI:10.29235/1814-6023-2023-20-3-256-264

E. V. Kravchenko, L. M. Olgomets, O. N. Savanets, K. V. Borodina, E. S. Pustyulga, V. Golubovich, R. D. Zilberman, N. Bizunok, B. Dubovik

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引用次数: 0

摘要

研究了含脯氨酸寡肽N-Ac-DSer-Pro-DArg-Gly-NH2 (B-4)、N-Ac-Trp-Pro-Arg-Gly-NH2 (B-5)、N-Ac-Tyr-Pro-Arg-Gly-NH2 (B-7)、Pro-Gly对雄性ICR小鼠强迫游泳行为的影响。N-Ac-DSer-Pro-DArg-Gly-NH2 (1.0 mcg/kg, i.n)增加了活跃游泳的强度，最明显的是在测试的最后2分钟(最大疲劳期)，即，它阻止了“绝望”行为。

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Effect of proline-containing oligopeptides on the behavior of outbred ICR mice in the Forced Swim Test

The effect of proline-containing oligopeptides N-Ac-DSer-Pro-DArg-Gly-NH2 (B-4), N-Ac-Trp-Pro-Arg-Gly-NH2 (B-5), N-Ac-Tyr-Pro-Arg-Gly-NH2 (B-7), and Pro-Gly on the behavior of male ICR mice in the Forced Swim Test was studied. N-Ac-DSer-Pro-DArg-Gly-NH2 (1.0 mcg/kg, i.n) increased the intensity of active swimming, most pronounced – during the last 2 minutes of testing (maximum fatigue period), i.e., it prevented the behavior of “despair”.

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来源期刊

Proceedings of the National Academy of Sciences of Belarus, Medical series Medicine-Medicine (all)

CiteScore

0.40

自引率

0.00%

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