{"title":"控制药物释放的聚(乙烯-醋酸乙烯)共混物","authors":"M. Akl, Abd-Elrazek Hm, Abdel Bary Em","doi":"10.21767/2321-547X.1000025","DOIUrl":null,"url":null,"abstract":"Ethylene vinyl acetate copolymer (EVA) was blended with polyvinyl acetate polymer (PVAc) to form EVA/PVAc blends. Paracetamol was used as a drug model in the investigated blends. Different weight ratios of the two polymers in the blend were investigated, these are (100/0, 80/20 50/50, 20/80, 0/100 w/w EVA/PVAc). The concentration of the drug was kept constant. The micro structure, as well as crystallinity and chemical composition of these blends were investigated. The scanning electron microscopy (SEM) has been conducted for blends before and after release. Crystallization behavior of EVA was investigated as well as X-ray diffraction (XRD) of the blends. Besides FTIR spectrum of the samples and equilibrium swelling and deswelling of the blends has been carried out.","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"12 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"Poly (Ethylene-Co-Vinyl Acetate) Blends for Controlled Drug Release\",\"authors\":\"M. Akl, Abd-Elrazek Hm, Abdel Bary Em\",\"doi\":\"10.21767/2321-547X.1000025\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Ethylene vinyl acetate copolymer (EVA) was blended with polyvinyl acetate polymer (PVAc) to form EVA/PVAc blends. Paracetamol was used as a drug model in the investigated blends. Different weight ratios of the two polymers in the blend were investigated, these are (100/0, 80/20 50/50, 20/80, 0/100 w/w EVA/PVAc). The concentration of the drug was kept constant. The micro structure, as well as crystallinity and chemical composition of these blends were investigated. The scanning electron microscopy (SEM) has been conducted for blends before and after release. Crystallization behavior of EVA was investigated as well as X-ray diffraction (XRD) of the blends. Besides FTIR spectrum of the samples and equilibrium swelling and deswelling of the blends has been carried out.\",\"PeriodicalId\":7704,\"journal\":{\"name\":\"American Journal of Advanced Drug Delivery\",\"volume\":\"12 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Advanced Drug Delivery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21767/2321-547X.1000025\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Advanced Drug Delivery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21767/2321-547X.1000025","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Poly (Ethylene-Co-Vinyl Acetate) Blends for Controlled Drug Release
Ethylene vinyl acetate copolymer (EVA) was blended with polyvinyl acetate polymer (PVAc) to form EVA/PVAc blends. Paracetamol was used as a drug model in the investigated blends. Different weight ratios of the two polymers in the blend were investigated, these are (100/0, 80/20 50/50, 20/80, 0/100 w/w EVA/PVAc). The concentration of the drug was kept constant. The micro structure, as well as crystallinity and chemical composition of these blends were investigated. The scanning electron microscopy (SEM) has been conducted for blends before and after release. Crystallization behavior of EVA was investigated as well as X-ray diffraction (XRD) of the blends. Besides FTIR spectrum of the samples and equilibrium swelling and deswelling of the blends has been carried out.
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