幽门螺杆菌感染的综合治疗

Abdul Ghaffar Hamzah, A. Fauzi
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引用次数: 0

摘要

幽门螺杆菌(Hp)感染是一种慢性革兰氏阴性细菌感染,感染胃上皮。这一患病率非常高,并因地理位置、种族、年龄和社会经济等因素而异。Hp感染的关键管理是准确的诊断和治疗。幽门螺杆菌诊断检查包括非侵入性检查和侵入性检查,最常见的非侵入性检查是血清学检查、尿素呼气试验(UBT)和粪便抗原试验,而侵入性检查是快速脲酶试验、组织病理学、培养和PCR。根除幽门螺杆菌的目标是治愈消化性溃疡,降低胃癌的风险。世界范围内推荐并在印度尼西亚使用的根除疗法是由PPI、克拉霉素和阿莫西林或甲硝唑组成的三联药联合疗法,疗程14天。根除治疗的成功在很大程度上取决于治疗方案的选择,患者对可能产生药物副作用的多种药物的依从性,以及幽门螺杆菌菌株对所消耗抗生素的敏感性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comprehensive Management of Helicobacter pylori Infection
Helicobacter pylori (Hp) infection is a chronic gram-negative bacterial infection, that infects the epithelium of the stomach. This prevalence is very high and varies depending on factors such as geographical location, ethnicity, age, and socioeconomic. The key management of Hp infection is accurate diagnosis and treatment. The H. pylori diagnostic examination consists of non-invasive and invasive tests, the most common non-invasive tests are serological tests, urea breath tests (UBT), and stool antigen tests, while invasive tests are rapid urease tests, histopathology, culture, and PCR. The goal of H. pylori eradication is to heal peptic ulcers and reduce the risk of gastric cancer. Eradication therapy that is recommended worldwide and used in Indonesia is the triple drug combination therapy consisting of a PPI, clarithromycin and amoxicillin or metronidazole for 14 days. The success of eradication therapy is highly dependent on the choice of therapeutic regimen, patient compliance in taking multi-drugs with possible drug side effects, and the sensitivity of H. pylori strains to the antibiotics consumed.
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