在健康大鼠中,火梨垂蝇水提物增强先天免疫反应,抑制获得性免疫反应,而软骨垂蝇水提物则相反

Elham H Algahdali, S. Mahassni
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摘要

火蚤(福斯克)Decne。(LP)和软骨脱落。(CC)是当地民间医学中使用的植物,尽管没有发表关于其生理,血液和免疫系统作用的研究。本研究首次确定并比较了石蜡提取物和石蜡提取物对健康白化病大鼠的体重参数、饲料和水的消耗以及血液样本中差异全血细胞计数的影响。6组大鼠(每组3只)分别灌胃浓度为30、100、200 mg/kg体重的LP (LP1、LP2、LP3组)和CC (CC1、CC2、CC3组)水提物,对照组3只大鼠灌胃水提物,每天灌胃2周。每天测量体重。各组之间、实验组与对照组之间、等浓度LP组与CC组之间的平均总体重均无显著差异。与对照组相比,LP3组的平均总体重增加、日体重增加和相对总体重增加百分比显著降低。LP2、LP3、CC2和CC3组的平均采食量极显著低于对照组,且LP3组显著低于CC3组。与对照组相比,LP3组的FER明显降低。CC1的平均淋巴细胞百分比显著高于对照组,LP1的平均淋巴细胞计数显著低于对照组。LP1的平均中性粒细胞百分比显著高于CC1, LP1和LP2的平均淋巴细胞百分比显著低于CC1和CC2。综上所述,LP提取物增强了小鼠的先天免疫反应,抑制了获得性免疫反应,而CC提取物则相反。因此,该提取物可用于调节免疫反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The aqueous extract of Leptadenia Pyrotechnica Decne enhances the innate immune response and inhibits the acquired immune response, while the aqueous extract of Capparis Cartilaginea Decne does the exact opposite in Healthy Rats
Leptadenia pyrotechnica (Forssk.) Decne. (LP) and Capparis cartilaginea Decne. (CC) are plants used in local folk medicine, although there are no published studies on their physiological, hematological, and immune system effects. This study is the first to determine and compare the effects of aqueous LP and CC extracts on body weight parameters, consumptions of feed and water, and the differential complete blood counts in blood samples of healthy Wister albino rats. Six groups of rats (3 rats/group) were orally gavage separately with the aqueous extracts of LP (groups LP1, LP2, and LP3, respectively) and CC (groups CC1, CC2, and CC3, respectively) at concentrations of 30, 100, and 200 mg/kg body weight, while three control rats were gavage with water, daily for two weeks. Body weights were measured daily. The mean total body weights were not significantly different between all groups, between the experimental groups and the control group, and between the equal concentrations of LP and CC groups. The mean total and daily body weight gains and percent relative total body weight gain for the LP3 group were significantly lower compared with the control group. The mean feed and water intakes were highly significantly lower for the LP2, LP3, CC2, and CC3 groups compared with the control group, and for the LP3 group it was significantly lower compared with the CC3 group. The FER for the LP3 group was significantly lower compared with the control group. The mean lymphocyte percent for CC1 was significantly higher and the mean lymphocyte count for LP1 was significantly lower compared with the control. The mean neutrophil percent for LP1 was significantly higher than for CC1 and the mean lymphocyte percents for LP1 and LP2 were significantly lower than for CC1 and CC2. In conclusion, the LP extract enhances the innate immune response and inhibits the acquired immune response, while the CC extract does the exact opposite. Thus, the extract may be used for modulating the immune response.
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