{"title":"复杂生物系统建模:通过进化解决参数诅咒","authors":"P. Hogeweg","doi":"10.32942/osf.io/safm4","DOIUrl":null,"url":null,"abstract":"In this perspective paper we review a previously published evolutionary model of the lac-operon to argue and demonstrate the importance of using evolutionary methods to derive relevant parameters. We show that by doing so we can debug experimental and modeling artifacts.","PeriodicalId":12324,"journal":{"name":"Evolutionary Systems Biology","volume":"2 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Modeling complex biological systems: Tackling the parameter curse through evolution\",\"authors\":\"P. Hogeweg\",\"doi\":\"10.32942/osf.io/safm4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this perspective paper we review a previously published evolutionary model of the lac-operon to argue and demonstrate the importance of using evolutionary methods to derive relevant parameters. We show that by doing so we can debug experimental and modeling artifacts.\",\"PeriodicalId\":12324,\"journal\":{\"name\":\"Evolutionary Systems Biology\",\"volume\":\"2 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-02-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Evolutionary Systems Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32942/osf.io/safm4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Evolutionary Systems Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32942/osf.io/safm4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Modeling complex biological systems: Tackling the parameter curse through evolution
In this perspective paper we review a previously published evolutionary model of the lac-operon to argue and demonstrate the importance of using evolutionary methods to derive relevant parameters. We show that by doing so we can debug experimental and modeling artifacts.
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