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引用次数: 2
摘要
本研究的目的是比较黑光决明子叶和树皮水提物的降糖活性。研究的各项参数包括对正常血糖大鼠空腹血糖水平的影响、对糖耐量试验的影响以及对链脲佐菌素诱导的糖尿病大鼠降糖活性的影响。水提物对糖尿病大鼠外糖负荷的影响有统计学意义(P < 0.001)。在慢性模型治疗中，与糖尿病大鼠相比，实验组(决明子皮提取物)在第21天降低空腹血糖水平的差异有统计学意义(P < 0.001)。这些结果表明，决明子树皮提取物在改善糖尿病大鼠的糖尿病状况方面具有显著的降糖潜力。对正常大鼠无明显影响。支持来源:作者衷心感谢克尔斯药学院院长F. V. Manvi博士为本工作提供必要的设施。
Comparative Hypoglycemic Effects of Cassia Glauca Lam. in Streptozotocin- Induced Diabetic Rats
The aim of this study was to evaluate comparative hypoglycemic activity of aqueous extract of Cassia glauca leaf and bark. The various parameters studied included effect on fasting blood glucose levels of normoglycemic rats, oral glucose tolerance test and hypoglycemic activity in streptozotocin induced diabetic rats. On oral administration , aqueous extract showed statistically significant (P < 0.001) effect by reducing the effect of external glucose load in diabetic rats. In chronic model of treatment, the difference between the experimental (Cassia glauca bark extract) rats in lowering the fasting plasma glucose levels was statistically significant (P < 0.001) as compared in diabetic rats on day 21. These findings suggest the significant hypoglycemic potential of the Cassia glauca bark extracts in ameliorating the diabetic conditions in diabetic rats. No significant effects were found in the normal rats. Source of Support: The authors sincerely thank Dr. F. V. Manvi, Principal, KLES’s College of Pharmacy for providing the necessary facilities for this work.
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