某三级护理教学医院精神科门诊患者药物不良反应及潜在药物相互作用的横断面研究

IF 0.3 Q4 PHYSIOLOGY

Physiology and Pharmacology Pub Date : 2021-09-01 DOI:10.52547/ppj.25.3.206

Adit Deshmukh, S. Dabhade

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引用次数: 0

摘要

前言:本研究的目的是利用Medscape软件(在线)记录和分析精神药物的不良反应(adr)、不同精神药物之间的潜在药物相互作用(pddi)以及精神药物与其他共开药物之间的潜在药物相互作用(pddi)。方法:对某三级教学医院精神科门诊就诊的患者进行横断面研究。对500张处方的adr和pddi进行分析。结果:32例(6.4%)患者共发生37例不良反应。抗精神病药物是最常见的药物组，奥氮平是最常见的疑似引起不良反应的精神药物。震颤是最常见的不良反应。所有不良反应都不严重，在收集数据时处于“恢复”状态。在调查的500张处方中，共有1051张处方存在pDDI，其中361张处方至少存在一种pDDI。结论:总体不良反应发生率不高(6.4%)，再次说明在本研究环境下应谨慎用药。大多数处方的处方只有1-2个pddi。

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A study of adverse drug reactions and potential drug-drug interactions in the patients attending the Psychiatric Outpatient Department in a Tertiary Care Teaching Hospital: a cross-sectional study

Introduction: The objective of this study was to record and analyze the adverse drug reactions (ADRs) due to psychotropic drugs and the potential drug-drug interactions (pDDIs) amongst different psychotropic drugs as well as pDDIs between psychotropic drugs and other co-prescribed drugs by using Medscape software (online). Methods: A cross sectional study was carried out in patients visiting the Psychiatric Outpatient Department of a Tertiary Care Teaching Hospital. Total 500 prescriptions were analysed for the ADRs and pDDIs. Results: Total 37 ADRs were observed in 32 (6.4%) patients. Antipsychotics was the most common group and olanzapine was the most common psychotropic drug suspected of causing ADRs. Tremors was the most common ADR observed. All of the ADRs were nonserious and were in a “Recovering” state when the data was collected. Total 1051 pDDIs were observed in all the 500 prescriptions surveyed, out of which 361 prescriptions were showing at least one pDDI. Conclusion: The overall incidence of ADRs was not very high (6.4%), which reiterates the judicious use of the drugs in the study setting. Majority of prescriptions had only 1-2 pDDIs per prescription.

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来源期刊

Physiology and Pharmacology PHYSIOLOGY-

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： Physiology and Pharmacology is the official English publication of the Iranian Society of Physiology and Pharmacology. The journal publishes Review articles, Full-length original articles, Letter to editor and Short communications in physiology, pharmacology and related subjects. The aim of this journal is to provide a medium of scientific communication for investigators in the field of Physiology and Pharmacology. The editors will welcome original basic and applied research articles from Physiologists and Pharmacologists. Articles should be in English language. The papers submitted to this journal must not be Published or under consideration for publication elsewhere. Physiology and Pharmacology is an open access journal which means that all contents is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search or link to the full text of the articles in this journal without asking prior permission from the publisher or the author.