钛表面镁涂层的生物相容性及其对骨髓间充质干细胞的影响

IF 2.9 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Technology Pub Date : 2022-09-28 DOI:10.1080/10667857.2022.2129318

X. Ni, Quanming Zhao, Xiao-yun Pan, Gang Zhao, Xingyuan Zhu, Liu-bao Ren, Jiong Yu, Baisheng Cai, Jiyang Tan, Jingyi Mi

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引用次数: 1

摘要

摘要表面改性可以有效地提高钛的生物活性，是目前研究的热点。在这项研究中，我们应用等离子体电解氧化(PEO)技术在Ti片表面制备了多孔Mg-TiO2涂层。然后，我们观察骨髓间充质干细胞(BMSCs)在Mg-TiO2涂层表面的粘附和增殖。结果表明:Mg- tio2涂层具有多孔结构，Mg在涂层表面和孔隙中分布均匀。多孔Mg-TiO2涂层具有良好的细胞相容性，无明显的细胞毒性。BMSCs在其表面的粘附和增殖明显高于纯Ti表面(p < 0.05)。综上所述，通过等离子体技术在Ti表面制备了具有良好表面形貌、良好生物相容性和生物活性的Mg-TiO2涂层，具有潜在的临床应用价值。

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Biocompatibility of a magnesium coating on a titanium surface and its effects on BMSCs

ABSTRACT Surface modification can effectively improve the biological activity of Ti, which is currently a popular research topic. In this study, we applied plasma electrolytic oxidation (PEO) technology to prepare a porous Mg-TiO2 coating on the surface of a Ti sheet. Then, we observed the adhesion and proliferation of bone marrow mesenchymal stem cells (BMSCs) on the surface of the Mg-TiO2 coating. The results showed that the Mg-TiO2 coating had a porous structure, and there was a uniform distribution of Mg on the surface and in the pores of the coating. The porous Mg-TiO2 coating showed good cytocompatibility and no obvious cytotoxicity. Significantly more BMSCs adhered to and proliferated on its surface than on pure Ti (p < 0.05). In conclusion, a Mg-TiO2 coating with a good surface morphology and good biocompatibility and bioactivity was prepared on a Ti surface by plasma technology and may have potential for clinical applications.

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来源期刊

Materials Technology 工程技术-材料科学：综合

CiteScore

6.00

自引率

9.70%

发文量

105

审稿时长

8.7 months

期刊介绍： Materials Technology: Advanced Performance Materials provides an international medium for the communication of progress in the field of functional materials (advanced materials in which composition, structure and surface are functionalised to confer specific, applications-oriented properties). The focus is on materials for biomedical, electronic, photonic and energy applications. Contributions should address the physical, chemical, or engineering sciences that underpin the design and application of these materials. The scientific and engineering aspects may include processing and structural characterisation from the micro- to nanoscale to achieve specific functionality.