{"title":"生物粘附和脱湿过渡","authors":"R. Bruinsma , E. Sackmann","doi":"10.1016/S1296-2147(01)01225-2","DOIUrl":null,"url":null,"abstract":"<div><p>The article discusses interferometric experiments carried out on a number of receptor/ligand (‘linker’) based bioadhesion systems. The aim was to quantitatively test the applicability of wetting theory to bioadhesion. In all cases phase-separation phenomena were observed, with highly heterogeneous adhesion disks, which is not consistent with a simple equilibrium wetting description. We present both theoretical and experimental evidence that these phenomena can be best understood in terms of two concepts: (I) a membrane-mediated linker–linker attraction, and (II) a linker-controlled dewetting transition.</p></div>","PeriodicalId":100307,"journal":{"name":"Comptes Rendus de l'Académie des Sciences - Series IV - Physics-Astrophysics","volume":"2 6","pages":"Pages 803-815"},"PeriodicalIF":0.0000,"publicationDate":"2001-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1296-2147(01)01225-2","citationCount":"30","resultStr":"{\"title\":\"Bioadhesion and the dewetting transition\",\"authors\":\"R. Bruinsma , E. Sackmann\",\"doi\":\"10.1016/S1296-2147(01)01225-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The article discusses interferometric experiments carried out on a number of receptor/ligand (‘linker’) based bioadhesion systems. The aim was to quantitatively test the applicability of wetting theory to bioadhesion. In all cases phase-separation phenomena were observed, with highly heterogeneous adhesion disks, which is not consistent with a simple equilibrium wetting description. We present both theoretical and experimental evidence that these phenomena can be best understood in terms of two concepts: (I) a membrane-mediated linker–linker attraction, and (II) a linker-controlled dewetting transition.</p></div>\",\"PeriodicalId\":100307,\"journal\":{\"name\":\"Comptes Rendus de l'Académie des Sciences - Series IV - Physics-Astrophysics\",\"volume\":\"2 6\",\"pages\":\"Pages 803-815\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1296-2147(01)01225-2\",\"citationCount\":\"30\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comptes Rendus de l'Académie des Sciences - Series IV - Physics-Astrophysics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1296214701012252\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comptes Rendus de l'Académie des Sciences - Series IV - Physics-Astrophysics","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1296214701012252","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The article discusses interferometric experiments carried out on a number of receptor/ligand (‘linker’) based bioadhesion systems. The aim was to quantitatively test the applicability of wetting theory to bioadhesion. In all cases phase-separation phenomena were observed, with highly heterogeneous adhesion disks, which is not consistent with a simple equilibrium wetting description. We present both theoretical and experimental evidence that these phenomena can be best understood in terms of two concepts: (I) a membrane-mediated linker–linker attraction, and (II) a linker-controlled dewetting transition.
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