{"title":"HIV相关眼病:现有认知和可能机制","authors":"Tie Zhao","doi":"10.35248/2155-9570.20.11.828","DOIUrl":null,"url":null,"abstract":"The Human Immunodeficiency Virus-1 (HIV-1) envelope protein gp120 is the major contributor to the pathogenesis of retinopathy and uveitis in HIV-1-related eye diseases. Disruption of the structure and function of the Blood-Retina Barrier (BRB) is the major contributor of HIV-1-related eye diseases and the molecular mechanism remains unknown. Our mini review revealed that retinopathy and uveitis are required for gp120- induced inflammation and epigenetic changes and suggest that gp120 regulate tight junction protein.","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"3 1","pages":"1-3"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"HIV Associated Eye Diseases: Existing Cognitive and Possible Mechanisms\",\"authors\":\"Tie Zhao\",\"doi\":\"10.35248/2155-9570.20.11.828\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The Human Immunodeficiency Virus-1 (HIV-1) envelope protein gp120 is the major contributor to the pathogenesis of retinopathy and uveitis in HIV-1-related eye diseases. Disruption of the structure and function of the Blood-Retina Barrier (BRB) is the major contributor of HIV-1-related eye diseases and the molecular mechanism remains unknown. Our mini review revealed that retinopathy and uveitis are required for gp120- induced inflammation and epigenetic changes and suggest that gp120 regulate tight junction protein.\",\"PeriodicalId\":15372,\"journal\":{\"name\":\"Journal of Clinical & Experimental Ophthalmology\",\"volume\":\"3 1\",\"pages\":\"1-3\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical & Experimental Ophthalmology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.35248/2155-9570.20.11.828\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical & Experimental Ophthalmology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35248/2155-9570.20.11.828","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
HIV Associated Eye Diseases: Existing Cognitive and Possible Mechanisms
The Human Immunodeficiency Virus-1 (HIV-1) envelope protein gp120 is the major contributor to the pathogenesis of retinopathy and uveitis in HIV-1-related eye diseases. Disruption of the structure and function of the Blood-Retina Barrier (BRB) is the major contributor of HIV-1-related eye diseases and the molecular mechanism remains unknown. Our mini review revealed that retinopathy and uveitis are required for gp120- induced inflammation and epigenetic changes and suggest that gp120 regulate tight junction protein.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
