小鼠肝星状细胞NAD(P)H醌脱氢酶1表达的双向调控——急性与长期乙醇暴露

Medical research archives Pub Date : 2023-01-01 DOI:10.18103/mra.v11i2.3586

H. Yang, Ningya Zhang, Zhongmao Guo

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引用次数: 0

摘要

结论:我们的研究结果表明，乙醇通过激活AhR-Nrf2通路上调NQO1的表达。长期乙醇暴露使AhR蛋白维持在低水平，并降低其靶基因Nrf2和NQO1被BaP诱导的能力。这些发现将有助于理解乙醇和多环芳烃化合物(如BaP)的协同毒性。

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Bidirectional Regulation of NAD(P)H Quinone Dehydrogenase 1 Expression in Mouse Hepatic Stellate Cells- Acute versus Long-Term Ethanol Exposure

Conclusions: Our findings suggest that ethanol upregulates NQO1 expression by activating the AhR-Nrf2 pathway. Long-term ethanol exposure sustains low level of AhR protein and diminishes the inducibility of its target genes Nrf2 and NQO1 by BaP. These findings will contribute to understanding the synergistic toxicity of ethanol and polycyclic aromatic hydrocarbon compounds, such as BaP.

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