Comparative Analysis of Nasal Therapy with Soluble and Liposomal Forms of Curcumin on Rats with Alzheimer’s Disease Model

The aim of this study was a comparative analysis of the efficacy of nasal therapy of curcumin soluble and liposomal forms of animals with a model of Alzheimer’s disease. Cognitive tests and immunity-enzyme analysis of cytokines were completed. On experimental model of Alzheimer’s disease in rats (intrahippocampus administration of 15 nМ Аβ42_Human) installed more efficient nasal therapy (1 month treatment) of curcumin liposome form (3.5 μg/animal daily) has turned out more efficient compared to its aqueous solution, both in terms of cognitive tests (the portion of the positive responses and latent period of the conditioned reflex reaction elimination) and in neuroinflammation (cytokines content (interleukin-1β, interleukin-6, interleukin-10, tumor necrosis factor α) in the brain sections: cerebral cortex and hippocampus of the rats with Alzheimer’s disease model). The data indicate a high anticytokine potential specifically of the liposomal form of curcumin.