-亚麻酸甲酯微乳液体系的理化性质及评价

Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry Pub Date : 2016-05-03 DOI:10.1080/15533174.2014.989580

Yi Li, Xiaoxi Gao, Changmin Hou, Kaifeng Yu

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引用次数: 1

摘要

本研究的目的是探讨使用微乳不经化学修饰的非肠外给药γ -亚麻酸甲酯的可能性。以PEG 400为共表面活性剂，制备了-亚麻酸甲酯和吐温80组成的微乳液。研究了配方变量对微乳液粒径的影响。TEM图像显示，微乳液的液滴呈球形。PCS制备的微乳体系(Tween 80: GLA = 3:1)的平均液滴尺寸约为50 nm，至少6个月无变化。

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Physicochemical Characterization and Evaluation of a Microemulsion System for Gamma-Linolenic Acid Methyl Ester

The purpose of this study was to investigate the possibility for parenteral delivery of Gamma-linolenic acid methyl ester without chemical modification using a microemulsion. Microemulsions composed of gamma-linolenic acid methyl ester and Tween 80 were prepared using PEG 400 as a cosurfactant. The effect of formulation variables on the particle size of the microemulsion was investigated. TEM image indicates the liquid droplets of the microemulsion are spheral shape. The mean droplet size of microemulsion system (Tween 80: GLA = 3:1) by PCS was about 50 nm and no changes were noted for at least six months.

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来源期刊

Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry 工程技术-纳米科技

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审稿时长

5 months