阿曼部分药用植物的体外抗癌活性研究

S. Said, Y. Tamimi, Akhtar, A. M. Weli, Suleiman Al-Khanjari, Qassim Al-Riyami
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引用次数: 4

摘要

本文报道了从芦荟(Aloe dhufarensis)、Calotropis procera、Juniperus servaschanica、Lawsonia inermis、Maytenus dhofarensis、Moringa peregrina、Polygala senensis、Punica granatum、Rhazya stricta、Solanum incanum、teucium mascatense等12种药用植物中提取的己烷、氯仿、乙酸乙酯、丁醇和水提取物的体外抗癌活性。和采自阿曼的扎塔里亚。将植物原料在乙醇中浸渍后得到的粗乙醇提取物进行库普坎分割,得到己烷、氯仿、乙酸乙酯、丁醇和水相馏分。用Alamar蓝法测定其对卵巢癌细胞株(MCAS)和乳腺癌细胞株(MDA MB231)的细胞毒性。五种植物C. procera、J. servaschanica、M. dhofarensis、S. incanum的13种提取物及原研论文Said等生物工程学报,15(5):1-8,2017;文章no.BJPR。324592t . mascatense对MCAS有活性;其中,枫香叶的己烷提取物活性最强,其次是白荆叶的氯仿提取物(IC50分别为8.50和10.90 μg/ml)。除原牛蒡外,其余9种提取物均能抑制MDA MB321的生长;皂液中正己烷提取物的活性最高,其次是皂液中的丁醇提取物。(IC50分别为11.4、19.44 μg/ml)。在这一温带、炎热气候地区生长的植物群的民族植物学和民族药理学信息可以为开发新的更有效的癌症化疗药物提供新的化学实体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In vitro Anticancer Activity of Selected Medicinal Plants from Oman
This paper reports in vitro anticancer activity of hexane, chloroform, ethyl acetate, butanol and water extracts obtained from twelve (12) medicinal plants including Aloe dhufarensis, Calotropis procera, Juniperus servaschanica, Lawsonia inermis, Maytenus dhofarensis, Moringa peregrina, Polygala senensis, Punica granatum, Rhazya stricta, Solanum incanum, Teucrium mascatense. and Zataria multiflora collected from Oman. Crude ethanol extracts prepared by maceration of plant materials in ethanol were Kupchan partitioned to give hexane, chloroform, ethyl acetate, butanol and aqueous fractions. Cytotoxicities of the prepared fractions were measured by Alamar blue assay against ovarian cancer cell line (MCAS) and breast cancer cell line (MDA MB231). Thirteen extracts from five plants C. procera, J. servaschanica, M. dhofarensis, S. incanum and Original Research Article Said et al.; BJPR, 15(5): 1-8, 2017; Article no.BJPR.32459 2 T. mascatense were found active against MCAS; hexane extract from J. servaschanica was the most active followed by chloroform extract from leaves of S. incanum (IC50 = 8.50 and 10.90 μg/ml, respectively). Furthermore, nine extracts from these plants except C. procera inhibited the growth of MDA MB321; hexane extract from J. servaschanica was again the most active followed by butanol extract of S. incanum. (IC50 = 11.4 and 19.44 μg/ml, respectively). Ethnobotanical and ethnopharmacological information on flora growing in this intemperate, hot climate region could provide new chemical entities for development of new and more potent cancer chemotherapeutics.
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