{"title":"血压昼夜节律脉动片的处方与优化","authors":"","doi":"10.46243/jst.2020.v5.i5.pp204-219","DOIUrl":null,"url":null,"abstract":"Circadian rhythm is a 24-hour cycle of human body, the body different aspect in the morning as compare\nto afternoon or night. The blood pressure rises in two time in a day, one is at early morning and second one is at\nevening.The aim of present project work was to design the pulsatile tablet for treatment of blood pressure with\ncombination drug therapy. in most cases it is seen that the increasing in Plasma norepinephrine level and plasma\nrenin activity in the morning; both hormones are potential to induce coronary vasoconstriction, therefore, there is a\nneed to a such formulation who achieve peak plasma concentration of drug at morning and can control morning\nspate of B.P. The pulsatile release of nebivolol after the lag time with sustain release of curcumin which maintain\nthe severity of blood Pressure. The Formulation of Core tablet of nebivolol was prepared by using superdisintegrate by direct compression with diluent. F10 batch was found to be optimized formulation as it shown\npotent drug release within short time. The lag time was prolonged with an increase of the coating level, whereas the\ndrug release rate was almost constant, irrespective of the coating level the lag time of nebivolol was found to be 8 to\n8.5hrsand drug release after 9hrs. drug release was above 95% after lag time with constant release of curcumin.\nHence, this approach can provide a useful means and may be helpful for patients with morning spate of BP and\ndevelopment of PDDS of combination drug therapy is a promising approach to overcome the side effect of single\ndrug i.e. nebivolol drug therapy and also oral drug delivery.","PeriodicalId":23534,"journal":{"name":"Volume 5, Issue 4","volume":"45 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Formulation and Optimization of Pulsatile Tablet for Circadian\\nRhythm of Blood Pressure\",\"authors\":\"\",\"doi\":\"10.46243/jst.2020.v5.i5.pp204-219\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Circadian rhythm is a 24-hour cycle of human body, the body different aspect in the morning as compare\\nto afternoon or night. The blood pressure rises in two time in a day, one is at early morning and second one is at\\nevening.The aim of present project work was to design the pulsatile tablet for treatment of blood pressure with\\ncombination drug therapy. in most cases it is seen that the increasing in Plasma norepinephrine level and plasma\\nrenin activity in the morning; both hormones are potential to induce coronary vasoconstriction, therefore, there is a\\nneed to a such formulation who achieve peak plasma concentration of drug at morning and can control morning\\nspate of B.P. The pulsatile release of nebivolol after the lag time with sustain release of curcumin which maintain\\nthe severity of blood Pressure. The Formulation of Core tablet of nebivolol was prepared by using superdisintegrate by direct compression with diluent. F10 batch was found to be optimized formulation as it shown\\npotent drug release within short time. The lag time was prolonged with an increase of the coating level, whereas the\\ndrug release rate was almost constant, irrespective of the coating level the lag time of nebivolol was found to be 8 to\\n8.5hrsand drug release after 9hrs. drug release was above 95% after lag time with constant release of curcumin.\\nHence, this approach can provide a useful means and may be helpful for patients with morning spate of BP and\\ndevelopment of PDDS of combination drug therapy is a promising approach to overcome the side effect of single\\ndrug i.e. nebivolol drug therapy and also oral drug delivery.\",\"PeriodicalId\":23534,\"journal\":{\"name\":\"Volume 5, Issue 4\",\"volume\":\"45 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-10-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Volume 5, Issue 4\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.46243/jst.2020.v5.i5.pp204-219\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Volume 5, Issue 4","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46243/jst.2020.v5.i5.pp204-219","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Formulation and Optimization of Pulsatile Tablet for Circadian
Rhythm of Blood Pressure
Circadian rhythm is a 24-hour cycle of human body, the body different aspect in the morning as compare
to afternoon or night. The blood pressure rises in two time in a day, one is at early morning and second one is at
evening.The aim of present project work was to design the pulsatile tablet for treatment of blood pressure with
combination drug therapy. in most cases it is seen that the increasing in Plasma norepinephrine level and plasma
renin activity in the morning; both hormones are potential to induce coronary vasoconstriction, therefore, there is a
need to a such formulation who achieve peak plasma concentration of drug at morning and can control morning
spate of B.P. The pulsatile release of nebivolol after the lag time with sustain release of curcumin which maintain
the severity of blood Pressure. The Formulation of Core tablet of nebivolol was prepared by using superdisintegrate by direct compression with diluent. F10 batch was found to be optimized formulation as it shown
potent drug release within short time. The lag time was prolonged with an increase of the coating level, whereas the
drug release rate was almost constant, irrespective of the coating level the lag time of nebivolol was found to be 8 to
8.5hrsand drug release after 9hrs. drug release was above 95% after lag time with constant release of curcumin.
Hence, this approach can provide a useful means and may be helpful for patients with morning spate of BP and
development of PDDS of combination drug therapy is a promising approach to overcome the side effect of single
drug i.e. nebivolol drug therapy and also oral drug delivery.