重建关节软骨的超声生物显微镜和磁共振成像

1997 IEEE Ultrasonics Symposium Proceedings. An International Symposium (Cat. No.97CH36118) Pub Date : 1997-10-05 DOI:10.1109/ULTSYM.1997.661781

K. Harasiewicz, H. Gahunia, C. Lemaire, N. Konyer, H.K.W. Kim, P. Babyn, K. Pritzker, F. Foster

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引用次数: 0

摘要

一种基于重建关节软骨的系统被用于促进无创成像方法的评估，如超声生物显微镜(UBM)和磁共振成像(MRI)，用于评估骨关节炎(OA)。分别从小腿关节软骨的浅层和深层分离培养软骨细胞。用白细胞介素1 (Il-1)处理部分培养物，研究其对软骨生长的影响。在第21、35和56天，用UBM、MRI和组织学检查软骨培养物。UBM、MRI和组织学测量的软骨厚度相似，相关系数分别为0.982 (P<0.0001)和0.998 (P<0.0001)。介绍了UBM图像与组织学和MRI的比较，并讨论了软骨实时UBM成像的潜在应用。

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Ultrasound biomicroscopy and magnetic resonance imaging of reconstituted articular cartilage

A system based on reconstituted articular cartilage is used to facilitate evaluation of noninvasive imaging methods such as ultrasound biomicroscopy (UBM) and magnetic resonance imaging (MRI) for assessment of osteoarthritis (OA). Chondrocytes from the superficial and deep layers of calf articular cartilage were isolated and cultured. Some cultures were treated with interleukin 1 (Il-1) and the effects on cartilage growth were studied. On days 21, 35, and 56 the cartilage cultures were examined using UBM, MRI, and histology. Cartilage thickness measured using UBM, MRI, and histology were similar with the correlation coefficients of 0.982 (P<0.0001) and 0.998 (P<0.0001) respectively. Comparisons of the UBM images with histology and MRI are presented and potential application of the real time UBM imaging of cartilage is discussed.

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1997 IEEE Ultrasonics Symposium Proceedings. An International Symposium (Cat. No.97CH36118)

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