星形星形细胞中钙缓冲的计算模型

Proceedings of the 2019 9th International Conference on Bioscience, Biochemistry and Bioinformatics - ICBBB '19 Pub Date : 2019-01-07 DOI:10.1145/3314367.3314379

A. Jha, B. Jha

{"title":"星形星形细胞中钙缓冲的计算模型","authors":"A. Jha, B. Jha","doi":"10.1145/3314367.3314379","DOIUrl":null,"url":null,"abstract":"Before last two decades, astrocytes were treated as supporting cells of neuron. Now it is regarded as important and strong participant in central nervous system. Astrocytes also play important role in many neuronal disorders like Alzheimer's, Parkinson's etc. Astrocytes release gliotransmitters like glutamate. Astrocytes take part in synapse in calcium dependent manner. However, it is not clear about the effect of astrocyte geometry on calcium distribution. In this study we present a geometry based mathematical model of an astrocytes. Mathematical model is developed in the form of reaction diffusion equation by considering the effect of endogenous and exogenous buffers on cytosolic calcium concentration. In present study it is concluded that the effect of geometry also visible and found significant on cytosolic calcium distribution in astrocytes.","PeriodicalId":20485,"journal":{"name":"Proceedings of the 2019 9th International Conference on Bioscience, Biochemistry and Bioinformatics - ICBBB '19","volume":"26 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Computational Modelling of Calcium Buffering in a Star Shaped Astrocyte\",\"authors\":\"A. Jha, B. Jha\",\"doi\":\"10.1145/3314367.3314379\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Before last two decades, astrocytes were treated as supporting cells of neuron. Now it is regarded as important and strong participant in central nervous system. Astrocytes also play important role in many neuronal disorders like Alzheimer's, Parkinson's etc. Astrocytes release gliotransmitters like glutamate. Astrocytes take part in synapse in calcium dependent manner. However, it is not clear about the effect of astrocyte geometry on calcium distribution. In this study we present a geometry based mathematical model of an astrocytes. Mathematical model is developed in the form of reaction diffusion equation by considering the effect of endogenous and exogenous buffers on cytosolic calcium concentration. In present study it is concluded that the effect of geometry also visible and found significant on cytosolic calcium distribution in astrocytes.\",\"PeriodicalId\":20485,\"journal\":{\"name\":\"Proceedings of the 2019 9th International Conference on Bioscience, Biochemistry and Bioinformatics - ICBBB '19\",\"volume\":\"26 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the 2019 9th International Conference on Bioscience, Biochemistry and Bioinformatics - ICBBB '19\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1145/3314367.3314379\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the 2019 9th International Conference on Bioscience, Biochemistry and Bioinformatics - ICBBB '19","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1145/3314367.3314379","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

近二十年来，星形胶质细胞一直被认为是神经元的支持细胞。现在被认为是中枢神经系统中重要而有力的参与者。星形胶质细胞在许多神经疾病如阿尔茨海默病、帕金森病等中也起着重要作用。星形胶质细胞释放谷氨酸等胶质递质。星形胶质细胞以钙依赖的方式参与突触。然而，星形胶质细胞的几何形状对钙分布的影响尚不清楚。在这项研究中，我们提出了一个基于几何的星形胶质细胞数学模型。考虑内源和外源缓冲液对胞质钙浓度的影响，建立了反应扩散方程的数学模型。本研究认为几何形状对星形胶质细胞胞质钙分布的影响也很明显。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Computational Modelling of Calcium Buffering in a Star Shaped Astrocyte

Before last two decades, astrocytes were treated as supporting cells of neuron. Now it is regarded as important and strong participant in central nervous system. Astrocytes also play important role in many neuronal disorders like Alzheimer's, Parkinson's etc. Astrocytes release gliotransmitters like glutamate. Astrocytes take part in synapse in calcium dependent manner. However, it is not clear about the effect of astrocyte geometry on calcium distribution. In this study we present a geometry based mathematical model of an astrocytes. Mathematical model is developed in the form of reaction diffusion equation by considering the effect of endogenous and exogenous buffers on cytosolic calcium concentration. In present study it is concluded that the effect of geometry also visible and found significant on cytosolic calcium distribution in astrocytes.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Proceedings of the 2019 9th International Conference on Bioscience, Biochemistry and Bioinformatics - ICBBB '19

自引率

0.00%

发文量